Citation: Ming Zhao, Yurong Xu, Jing Lin, Hu Chen. 氮杂环卡宾催化的Michael加成反应[J]. University Chemistry, ;2022, 37(6): 210805. doi: 10.3866/PKU.DXHX202108056 shu

氮杂环卡宾催化的Michael加成反应

Department of Chemistry and Chemical Engineering, Hefei Normal University, Hefei 230601, China

Corresponding author: Ming Zhao, zhaomnwu@126.com
Received Date: 17 August 2021

Michael加成反应是有机化学中的重要反应，作为有机催化剂的氮杂环卡宾也能够催化Michael加成反应。本文主要对氮杂环卡宾催化的Michael加成反应进行了详细介绍，氮杂环卡宾可以和醛进行结合，形成具有亲核性的Breslow中间体，醛的反应极性由亲电性转变为亲核性，极性反转的醛与α，β-不饱和酮、酯等Michael受体发生加成反应，即Stetter反应；氮杂环卡宾也可以作为Brønsted碱，活化醇等发生Michael加成反应。对于氮杂环卡宾催化的Michael加成反应的介绍，能够丰富和拓展基础教学中Michael加成反应知识点的内容，有利于学生了解学科的前沿发展，激发学生的学习兴趣。
- N-Heterocyclic carbene,
- Michael addition,
- Organocatalysis,
- Brønsted base
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