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Citation: Aidang Lu, Lin Li, Shaoyang Shi, Yanjun Jiang. 综合化学实验：5-溴-1-甲基芦竹碱衍生物的制备和表征[J]. University Chemistry, ;2022, 37(3): 210503. doi: 10.3866/PKU.DXHX202105032 shu

综合化学实验：5-溴-1-甲基芦竹碱衍生物的制备和表征

School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, China

Received Date: 17 May 2021

设计了题为“5-溴-1-甲基芦竹碱衍生物制备和表征”的综合实验，以5-溴吲哚为原料，经Hofmann烷基化反应和Mannich反应成功制备重要中间体5-溴-1-甲基芦竹碱，然后与不同的酸反应制备系列5-溴-1-甲基芦竹碱衍生物。结合化合物合成及表征，既能提高学生的综合实验能力，又能培养其对科学研究的兴趣和创新探索的精神。
- Comprehensive experiment,
- Gramine derivatives,
- Mannich reaction,
- Salification reaction
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