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Citation: Shenghong Zhang, Chuansong Qi, Hua Rong, Liangfa Gong, Wei Li. 阿司匹林水解反应动力学参数测定实验的改进[J]. University Chemistry, ;2021, 36(8): 201005. doi: 10.3866/PKU.DXHX202010054 shu

阿司匹林水解反应动力学参数测定实验的改进

School of Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, China

Corresponding author: Wei Li, liwei77@bipt.edu.cn
Received Date: 23 October 2020

阿司匹林水解反应动力学是药学、医学类专业物理化学理论教学中的典型案例，其动力学参数的测定通常采用络合显色法，存在实验步骤繁琐且耗时过长等问题，难以转化为物理化学实验教学内容。为解决上述问题，改进了紫外分光光度法测定阿司匹林水解反应动力学的方法并详细探讨了其实验原理。和络合显色法相比，新方案大幅简化了实验内容和步骤，避免了含酸废液的产生并将反应时间缩短为4小时。改进后的实验项目有望发展为药学和医学类专业的化学动力学教学实验。
- Aspirin,
- Acetylsalicylic acid,
- Hydrolysis,
- Kinetics,
- Spectrophotometry
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
  Marrs, P. S. J. Chem. Educ. 2004, 81 (6), 870.
12. [12]
  Connors, K. A.; Amidon, G. L.; Stella, V. J.Chemical Stability of Pharmaceuticals, 1st ed.; John Wiley & Sons, Inc.:Philadelphia, USA, 1986; pp. 222-223.
13. [13]
1. [1]
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2. [2]
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