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Citation: LI Wanmei. Continuous Synthesis of (E)Benzalacetonein Microchannel Reactor: An Introduction of a Comprehensive Chemical Experiment[J]. University Chemistry, ;2019, 34(5): 51-56. doi: 10.3866/PKU.DXHX201810009 shu

Continuous Synthesis of (E)Benzalacetonein Microchannel Reactor: An Introduction of a Comprehensive Chemical Experiment

LI Wanmei

Provincial Experimental Teaching Demonstrating Center, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, P. R. China

Received Date: 10 October 2018

Micro-reaction is an emerging technology that has been developing rapidly in recent years in all research fields of chemistry. In this experiment, benzaldehyde and acetone were used as the starting materials, thus (E)benzalacetone was continuously synthesized by condensation reaction in the presence of sodium hydroxide. By investigating effects of mole ratio, residence time and reaction temperature, the optimized reaction conditions were determined. The product was characterized by NMR and MS. Compared with traditional batch synthetic methods, the presented method has the advantages of high yield, simple operation, and reproducible experimental results. This work gives advanced technology and ideas in laboratory teaching, which not only enhances students' experimental skills, but also helps students to understand the frontiers of science, research situation, tendency of development and application prospects, as well as inspire students' interest greatly.
- (E)Benzalacetone,
- Microchannel reactor,
- Continuous synthesis,
- Comprehensive experiment
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