Citation: DING Bo, XIE Jianjun, WANG Zhiyuan, TAO Yiwen, HUANG Hongbo, CHEN Wenrui, YAO Xiaobao. Advances in development and application of liquid chromatography coupled with isotope ratio mass spectrometry[J]. Chinese Journal of Chromatography, ;2020, 38(6): 627-638. doi: 10.3724/SP.J.1123.2019.12007 shu

Advances in development and application of liquid chromatography coupled with isotope ratio mass spectrometry

DING Bo ^1,2,, ,
XIE Jianjun ² ,
WANG Zhiyuan ² ,
TAO Yiwen ¹ ,
HUANG Hongbo ¹ ,
CHEN Wenrui ² ,
YAO Xiaobao ^3,4

1.
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China;
2.
Guangzhou Customs Technology Center, Guangzhou 510623, China;
3.
Qinghai Province Association of Ophiocordyceps sinensis, Xining 810007, China;
4.
Qinghai Gongcao Biotechnology Co. Ltd., Xining 810007, China

Corresponding author: DING Bo, dingbo@mail2.sysu.edu.cn
Received Date: 3 December 2019

Fund Project: Science & Technology Plan Project of Guangdong Province of China (No. 2016A040403091)

The first commercial interface for hyphenating liquid chromatography with isotope ratio mass spectrometry (LC-IRMS) was not available until 2004, and it was commercialized under the name LC IsoLink by Thermo Finnigan. LC-IRMS, a method of compound-specific isotope analysis, has enabled the detection of stable carbon isotope ratios (δ¹³C) in targeted substances in order to determine their origin and authenticity. This paper provides an overview of IRMS and LC-IRMS techniques, the history and detailed classification of the latter over the past twenty years. The application of LC-IRMS to the fields of food safety, environment and ecology, life sciences, and archeology are reviewed. Finally, the technical limitations, current challenges, and future development trends of LC-IRMS are outlined.
- isotope ratio mass spectrometry (IRMS),
- liquid chromatography (LC),
- compound-specific isotope analysis,
- δ¹³C,
- review
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