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Citation: XIE Ji'an, LIU Bolin, ZHAO Ziwei, ZHANG Lei, YANG Dajin, ZHAO Yunfeng. Application of isotope dilution-liquid chromatography-tandem mass spectrometry in the preparation and certification of reference material of tenuazonic acid and tentoxin in wheat flour[J]. Chinese Journal of Chromatography, ;2020, 38(7): 833-840. doi: 10.3724/SP.J.1123.2019.12005 shu

Application of isotope dilution-liquid chromatography-tandem mass spectrometry in the preparation and certification of reference material of tenuazonic acid and tentoxin in wheat flour

XIE Ji'an ^1,, ,
LIU Bolin ¹ ,
ZHAO Ziwei ¹ ,
ZHANG Lei ² ,
YANG Dajin ² ,
ZHAO Yunfeng ²

1.
Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, China;
2.
China National Center for Food Safety Risk Assessment, Beijing 100050, China

Corresponding author: XIE Ji'an, 16615925@qq.com
Received Date: 9 December 2019

Fund Project: National Key Research and Development Program of China (No. 2017YFC1601302)

A method for the preparation and certification of the reference material of tenuazonic acid (TeA) and tentoxin (TEN) in wheat flour was developed. This method provided methodological references to develop of standard material for analyzing alternaria toxins in grains. The wheat flour reference materials were based on wheat grains which were naturally contaminated with alternaria toxins. The certified values for TeA and TEN were determined by isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) and cooperated certification of multiple laboratories. The wheat flour reference materials were stored at room temperature, protected from light and characterized by low uncertainty. The wheat flour reference materials are currently the only wheat flour reference materials that naturally contaminate TeA and TEN, and it can be used in the evaluating related analytical methods involved in food safety risk monitoring, product quality testing and quality control measurements.
- liquid chromatography-tandem mass spectrometry (LC-MS/MS),
- reference material,
- tenuazonic acid (TeA),
- tentoxin (TEN),
- alternaria toxins,
- wheat flour
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