Citation: CEN Jianbin, LIANG Zhisen, OU Shuojun, HUANG Jiale, LI Xiuying, LIN Qinglan, CHEN Yuzhen, LIU Xinjie, LIN Senyu. Simultaneous determination of five baicaleins in healthy product tablets by dispersive solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2020, 38(6): 672-678. doi: 10.3724/SP.J.1123.2019.11008 shu

Simultaneous determination of five baicaleins in healthy product tablets by dispersive solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry

Guangzhou Inspection and Testing Certification Group Company Limited, National Quality Testing Center for Processed Food, Guangzhou 511447, China

Corresponding author: LIN Senyu, 150048985@qq.com
Received Date: 11 November 2019

A method based on dispersive solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry (DSPE-HPLC-MS/MS) was developed for the simultaneous determination of five analytes scutellarein, 4'-hydroxywogonin, norwogonin, baicalein, and wogonin in healthy product tablets. The samples were extracted with 10 mL acetone and purified on 75 mg C₁₈. The types and dosages of the extracted solvents and adsorbents were optimized. The results showed that these five analytes exhibited good linear relationships in their respective linear ranges. The correlation coefficients (r) were more than 0.99. The detection limits and quantitative limits were 0.5-40 μg/kg and 2.0-120 μg/kg, respectively. Recovery tests were carried out using three kinds of health product tablet matrices. The concentrations were one, five, and ten times the quantitative limit. The average recovery of these five targets was 83.1% to 106.5%, with relative standard deviations (RSDs) ranging from 0.97% to 4.52%. This method is easy to operate, and it shows high sensitivity and good reproducibility. Thus, it is suitable for the simultaneous determination of the target compounds in health tablets.
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