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Citation: WU Yan, ZHANG Xi, ZHANG Jie, ZHANG Xueqin, SHEN Heqing. Metabolomic network analysis of umbilical cord blood of gestational diabetes mellitus patients via liquid chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, ;2019, 37(8): 897-903. doi: 10.3724/SP.J.1123.2019.02006 shu

Metabolomic network analysis of umbilical cord blood of gestational diabetes mellitus patients via liquid chromatography-mass spectrometry

WU Yan ^1,2, ,
ZHANG Xi ^1,2 ,
ZHANG Jie ¹ ,
ZHANG Xueqin ³ ,
SHEN Heqing ¹

1.
Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China;
3.
Xiamen Maternity and Child Health Care Hospital, Xiamen 361003, China

Received Date: 15 February 2019

Fund Project: National Natural Science Foundation of China (Nos. 21677141, 91543113, 21777157).

The global increase in the prevalence of gestational diabetes mellitus(GDM)in recent years has prompted the study of the effect of GDM on the metabolism between mother and fetus. In this study, the metabolomic investigation of the umbilical cord blood of mothers presenting GDM was performed using liquid chromatography-mass spectrometry (LC-MS), orthogonal projections to latent structures discriminant analysis (OPLS-DA), and network analysis to assess GDM-related metabolic biomarkers. The results showed that arachidonic acid (AA) played an important role in the key metabolic network while further pathway analysis suggested that GDM induced unsaturated fatty acid metabolic disorder. This study provides the underlying metabolic mechanism of GDM-induced metabolic abnormalities between mother and fetus.
- liquid chromatography-mass spectrometry (LC-MS),
- metabolomics,
- network analysis,
- fatty acids,
- gestational diabetes mellitus (GDM)
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