Citation: LIU Lukuan, YANG Kaiguang, LIANG Zhen, ZHANG Lihua, ZHANG Yukui. Advances in capture methods of circulating tumor cells[J]. Chinese Journal of Chromatography, ;2019, 37(4): 358-366. doi: 10.3724/SP.J.1123.2018.12016 shu

Advances in capture methods of circulating tumor cells

1.
CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China;
3.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

Received Date: 10 December 2018

Fund Project: National Key Research and Development Program of China (Nos. 2017YFA0505003, 2016YFA0501401)

Since circulating tumor cells (CTCs) in the blood carry the genetic and phenotypic information of tumor tissues, they are regarded as important markers for liquid biopsy, especially for the early diagnosis of cancer, determination of treatment options and evaluation of prognosis. However, the capture and detection of CTCs is challenging because of their extremely low concentration in blood. In this review, recent advances in capture methods of CTCs based on their biophysical properties, affinity, and artificial antibodies are summarized. The advantages and drawbacks of these methods are discussed from the aspects of capture efficiency, capture purity and maintenance of activity after release. Future trends in CTCs capture are also discussed.
- circulating tumor cells (CTCs),
- selective capture,
- biophysics,
- affinity,
- artificial antibody,
- review
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