Citation: WANG Zhaodi, ZHANG Lu, GUO Bingqian, WANG Shige, HUANG Mingxian. Preparation of mixed-mode stationary phase for high performance liquid chromatography with ground hybrid silica monolithic material[J]. Chinese Journal of Chromatography, ;2019, 37(5): 484-490. doi: 10.3724/SP.J.1123.2018.11040 shu

Preparation of mixed-mode stationary phase for high performance liquid chromatography with ground hybrid silica monolithic material

Department of Chemistry, College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China

Received Date: 28 November 2018

Fund Project: Science and Technology Commission of Shanghai Municipality Project (No.14440502300)

With polyethylene glycol as a porogen, vinyltrimethoxysilane (VTMS) and tetramethoxysilane (TMOS) as silica precursors, a hybrid silica monolithic material was obtained under the catalysis of acetic acid and thermally decomposed urea. The silica monolithic material was ground by a ballmill, treated with tris(hydroxymethyl)aminomethane (Tris), then washed and dried to obtain silica particles with particle size~3 μm. The effects of different reaction conditions on the particle size, surface morphology and dispersibility of silica particles were investigated. When the volume ratio of TMOS to VTMS was 3:1, it was observed that silica particles with a pore diameter of 7.5 nm and a specific surface area of 245 m²/g were obtained. The resultant silica particles were modified by binding with chlorodimethyloctadecylsilane (C18) and by the thiol-ene click reaction to obtain a mixed-mode type stationary phase. The test results showed that the silica packing materials prepared in this work has certain applicability.
- silica monolith material,
- bonded stationary phase,
- thiol-ene click reaction,
- mixed-mode stationary phase
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