Citation: CAO Yuhong, ZHANG Mingyong, LIU Min, HONG Zhanying. Research advancement in the determination of neurotransmitters in biological samples and their applications[J]. Chinese Journal of Chromatography, ;2019, 37(3): 265-273. doi: 10.3724/SP.J.1123.2018.10006 shu

Research advancement in the determination of neurotransmitters in biological samples and their applications

1.
Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical(Chinese Materia Medica) Metabolites Research, Shanghai 200433, China;
2.
Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Received Date: 8 October 2018

Fund Project: National Natural Science Foundation of China (No. 81673386).

Neurotransmitters (NTs) are endogenous chemical messengers that are involved in nerve signal transmission and play important roles in brain function. Changes in NT concentrations in the central nervous system are related to many mental and physiological illnesses. The determination of various NTs has become important in disease diagnosis, monitoring, and treatment interventions. Effective monitoring of NTs in vivo is essential for disease diagnosis and treatment as well as for the research and development of new drugs. This article provides a review of the methods used in NT detection in recent years, including instrumental and electrochemical techniques as well as some new detection methods, and summarizes the applications of the methods for NT detection in some diseases.
- liquid chromatography-mass spectrometry (LC-MS),
- quantitative detection,
- neurotransmitters (NTs),
- Alzheimer disease (AD),
- review
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