Citation: SONG Wei, ZHAO Muyu, HAN Fang, LÜ Yaning, DING Lei, ZHOU Dianbing, DENG Xiaojun, HU Yanyun, ZHENG Ping, SHENG Xuan. Determination of 39 veterinary drug residues in Procambarusclarkii by ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry[J]. Chinese Journal of Chromatography, ;2018, 36(12): 1261-1268. doi: 10.3724/SP.J.1123.2018.08037 shu

Determination of 39 veterinary drug residues in Procambarusclarkii by ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry

SONG Wei ^1,2, ,
ZHAO Muyu ¹ ,
HAN Fang ^1,2 ,
LÜ Yaning ^1,2 ,
DING Lei ¹ ,
ZHOU Dianbing ¹ ,
DENG Xiaojun ³ ,
HU Yanyun ^1,2 ,
ZHENG Ping ^1,2 ,
SHENG Xuan ¹

1.
Technical Center for Inspection and Quarantine of Anhui Entry-Exit Inspection and Quarantine Bureau, Hefei 230022 China;
2.
Anhui Province Key Laboratory of Analysis and Detection for Food Safety, Hefei 230022, China;
3.
Technical Center for Animal Plant and Food Inspection and Quarantine, Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China

Received Date: 25 August 2018

Fund Project: Linkage Research Project for Public Welfare in Anhui (No. 1704f0804057)

An ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed for determination of 39 veterinary drugs in Procambarusclarkii. Samples were extracted with acidified acetonitrile and purified with enhanced matrix removal-lipid (EMR-Lipid) adsorbent and graphitized multi-walled carbon nanotubes (GMWNTs). Extracts were analyzed by UHPLC-Q-TOF-MS. Target compounds were screened according to accurate mass, isotopic ratio, and retention time, and confirmed by library search. Target analytes were quantified using the chromatographic peak area of each compound. For each of the drugs of interest, calibration curves were linear in their respective ranges with correlation coefficients greater than 0.99. The limits of quantification (LOQs) were 3-15 μg/kg. The recoveries for target compounds spiked in Procambarusclarkii ranged from 62.4% to 105.8%, with relative standard deviations (RSDs) ranging from 2.5% to 13.5%. This method is simple, rapid, accurate, and suitable for simultaneous determination of 39 veterinary drugs, including sulfonamides, quinolones, and triphenylmethane, extracted from Procambarusclarkii.
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