Citation: SONG Yue, ZHANG Xining, ZHANG Wei, QIAN Yongzhong, QIU Jing. Stereoselective effects of ibuprofen on adult zebrafish brain tissues based on sphingolipidomics[J]. Chinese Journal of Chromatography, ;2018, 36(11): 1088-1098. doi: 10.3724/SP.J.1123.2018.04020 shu

Stereoselective effects of ibuprofen on adult zebrafish brain tissues based on sphingolipidomics

SONG Yue ^1,2,3, ,
ZHANG Xining ^1,2 ,
ZHANG Wei ^1,2 ,
QIAN Yongzhong ^1,2 ,
QIU Jing ^1,2

1.
Institute of Quality Standard and Testing Technology for Agro-Products of Chinese Academy of Agricultural Sciences, Beijing 100081, China;
2.
Key Laboratory of Agri-food Quality and Safety, Ministry of Agriculture, Beijing 100081, China;
3.
Shandong LaiBo Biotechnology Co. Ltd., Jinan 250000, China

Received Date: 17 April 2018

Fund Project: National Natural Science Foundation of China (No. 21477161)

The aim of this study was to investigate the stereoselective effects of a popular pharmaceutical and personal care product component ibuprofen (IBU) on adult zebrafish using sphingolipidomics. Sphingolipidomics is an effective method developed to determine sphingolipids present in biological samples using ultra-high performance liquid chromatography-triple quadrupole linear ion trap mass spectrometry. Using this method, 46 sphingolipids in adult zebrafish brain samples were quantified after rac-/R-(-)-/S-(+)-IBU exposure, and the biomarkers were selected using chemometric approaches, including principal component analysis and orthogonal partial least squares discrimination analysis. Besides, combined with the results of the Duncan post hoc test and Dunnett post hoc comparison, sphingolipidomic perturbations were found to be induced after exposure to ibuprofen at environmental concentrations, and enantiomers of ibuprofen had stereoselective effects on zebrafish. This study may provide a new insight on the influence of ibuprofen on aquatic organisms.
- ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS),
- ibuprofen,
- enantiomers,
- zebrafish,
- sphingolipid,
- lipidomics
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