Citation: SUN Shanshan, ZHU Lijun, HU Yanxi, LIU Yufeng, XU Liang. Determination of sedative and β-receptor hormone residues in feed by ultra high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2018, 36(2): 150-158. doi: 10.3724/SP.J.1123.2017.10025 shu

Determination of sedative and β-receptor hormone residues in feed by ultra high performance liquid chromatography-tandem mass spectrometry

SUN Shanshan ^1, ,
ZHU Lijun ¹ ,
HU Yanxi ¹ ,
LIU Yufeng ^1,2 ,
XU Liang ^1,2

1.
College of Pharmacy, Liaoning University, Shenyang 110036, China;
2.
Natural Products Pharmaceutical Engineering Technology Research Center of Liaoning Province, Shenyang 110036, China

Received Date: 25 October 2017

Fund Project: National Natural Science Foundation of Youth Science Foundation, China (No.81403177)

An analysis and detection method for eight sedatives and fifteen β-receptor hormones in feed was established by ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The sample was extracted with acetonitrile-1% (v/v) trichloroacetic acid aqueous solution (7:3, v/v), and purified by cationic solid phase extraction column. The extracts were separated on an Agilent Zorbax Eclipse Plus C₁₈ chromatographic column (100 mm×3.0 mm, 1.8 μm) and then quantified via internal standard method. The results showed that the linear relationships of the 23 targets were good in the range of 2.0-200.0 μg/L (r²> 0.99). The average recoveries of the targets spiked in the matrix of feed samples were within 75.1%-102.4% in three spiked levels of 5.0, 10, 50 μg/kg, and the relative standard deviations (RSDs) were within 4.3%-14.3% (n=6). This method with high purification efficiency and extensive scope of application can be applied to screening and detecting sedatives and β -receptor hormones in feed.
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