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Citation: ZHANG Xianchen, LI Rong, ZHANG Pengjie, WU Xia, HUA Hongbo, YANG Luqi, LU Junwen, RONG Yutang. Rapid determination of 25 drug residues in aquatic products by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry[J]. Chinese Journal of Chromatography, ;2018, 36(2): 114-124. doi: 10.3724/SP.J.1123.2017.10010 shu

Rapid determination of 25 drug residues in aquatic products by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry

ZHANG Xianchen ^1, ,
LI Rong ¹ ,
ZHANG Pengjie ¹ ,
WU Xia ² ,
HUA Hongbo ³ ,
YANG Luqi ¹ ,
LU Junwen ¹ ,
RONG Yutang ¹

1.
Inspection and Quarantine Technology Center of Zhongshan Entry-Exit Inspection and Quarantine Bureau, Zhongshan 528403, China;
2.
Agilent Technologies Co., Ltd. (China), Guangzhou 510000, China;
3.
Zhongshan ZhuoYa Foreign Language School, Zhongshan 528401, China

Received Date: 12 October 2017

Fund Project: Science and Technology Plan Project of Guangdong Province of China (No.2015A050502010)

An ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (UPLC-Q Orbitrap HRMS) method was developed for the rapid screening of 25 drug residues in aquatic products by the application of a novel enhanced matrix removal of lipids (EMR-Lipid). The samples were extracted with acetonitrile, cleaned-up with EMR-Lipid, and salted out with 3.0 g sodium chloride and 3.0 g sodium sulfate. The separation of the 25 drug residues was performed on an ACQUITY UPLC BEH C18 column (100 mm×2.1 mm, 1.7 μm) with gradient elution. Acetonitrile containing 0.1% (v/v) formic acid and 0.1% (v/v) formic acid aqueous solution were used as mobile phases. The compounds were detected by Full scan/date dependent MS/MS (Full MS/dd-MS²) via heated electrospray ionization (HESI) source. The calibration curves were linear with correlation coefficients (r) greater than 0.997. The limits of detection (LODs) ranged from 0.1 μg/kg to 1.0 μg/kg. The average spiked recoveries of the 25 target compounds were between 70.1% and 108.9% with relative standard derivations (RSDs) from 2.1% to 13.8%. Compared with the previous methods, this method has characteristics of simpler sample preparation and higher sensitivity.
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