Citation: CHEN Jiao, SHI Hao. Research progress of bonded chiral stationary phases[J]. Chinese Journal of Chromatography, ;2017, 35(12): 1229-1239. doi: 10.3724/SP.J.1123.2017.09017 shu

Research progress of bonded chiral stationary phases

CHEN Jiao ,
SHI Hao

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China

Received Date: 8 September 2017

Fund Project: Natural Science Foundation of Zhejiang Province (No. LY13B020013).

Chiral separation is important in biological medicine and other fields. High performance liquid chromatography (HPLC) is widely used in chiral separation and analysis for its economic, rapid and efficient characteristics. Chiral stationary phase (CSP) is the key to achieve chiral resolution in HPLC. Meanwhile, the key to preparing effective CSP is the screening of chiral selector. In recent years, a lot of CSPs with different chiral selectors had been prepared. Silica gel immobilized CSP is especially attached great attention because of its high solvent tolerance and stability. In this paper, the new type of CSPs prepared by using chiral single molecules, polysaccharides, cyclodextrins, macrocyclic antibiotics, crown ethers, calixarenes and alkaloids as chiral selectors are summarized, and the development prospect of immobilized CSPs are also discussed.
- immobilized chiral stationary phase,
- high performance liquid chromatography (HPLC),
- chiral separation,
- review
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