Citation: LI Rong, YANG Luqi, ZHANG Pengyun, LUO Yangdan, ZHANG Pengjie, GAO Yongqing. Determination of 64 veterinary drug residues in aquatic products by ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high-resolution mass spectrometry[J]. Chinese Journal of Chromatography, ;2017, 35(12): 1266-1275. doi: 10.3724/SP.J.1123.2017.08021 shu

Determination of 64 veterinary drug residues in aquatic products by ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high-resolution mass spectrometry

1.
Inspection and Quarantine Technology Center, Zhongshan Entry-Exit Inspection and Quarantine Bureau, Zhongshan 528400, China;
2.
School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China

Received Date: 28 August 2017

Fund Project: Science and Technology Planning Project of Guangdong Province of China (Nos. 2015A050502010, 2014A040401011)

A method has been developed for the simultaneous determination of 64 veterinary drugs in aquatic products using ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high-resolution mass spectrometry. The samples were extracted with an acetonitrile/water mixture (80/20, v/v), cleaned up by normal hexane saturated with acetonitrile and primary secondary amine (PSA) adsorbent, quantified with external standard method. The drugs were analyzed in full scan/data dependent mass spectrum 2 (Full MS/ddMS²) Top 1 mode. The calibration curves of the 64 drugs were linear with the correlation coefficients more than 0. 9967. The average recoveries of the 64 analytes ranged from 56.2% to 124.6%, and the relative standard deviations (RSDs) were 1.3%-29.8% in the three kinds of matrixes (fish, shrimp and shell) at three levels. The limits of quantification were 0.2-10 μg/kg. The method is simple, rapid, sensitive, reliable and suitable for the screening of residues in aquatic products.
- ultra-high performance liquid chromatography (UHPLC),
- high-resolution mass spectrometry (HRMS),
- veterinary drug,
- aquatic products,
- residue
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