Citation: ZHANG Xiuyao, CAI Xinxin, ZHANG Xiaoyi, LI Ruifen. Fast determination of pericarpium papaveris illegally added in foods by TurboFlow online purification-ultra performance liquid chromatography-triple quadrupole/linear ion trap mass spectrometry[J]. Chinese Journal of Chromatography, ;2017, 35(11): 1137-1144. doi: 10.3724/SP.J.1123.2017.06027 shu

Fast determination of pericarpium papaveris illegally added in foods by TurboFlow online purification-ultra performance liquid chromatography-triple quadrupole/linear ion trap mass spectrometry

Wenzhou Municipal Center for Disease Control and Prevention, Wenzhou 325001, China

Received Date: 27 June 2017

A fast confirmation method was developed for the determination of the six markers of pericarpium papaveris, morphine, codeine, narcotine, papavarine, thebaine and protopine in foods, by TurboFlow online purification-ultra performance liquid chromatography-triple quadrupole/linear ion trap mass spectrometry (TF-UPLC-QTRAP MS). The sample was extracted with 0.10 mol/L HCl. After the procedure of removal of lipid with hexane, the extraction solution was analyzed by TF-UPLC-QTRAP MS. The main factors influencing the purification efficiency including TurboFlow column, mobile phase and elution solution were optimized. The six opium alkaloids were detected by positive electrospray ionization tandem mass spectrometry in the multiple reaction monitoring-information-dependent acquisition-enhanced product ion (MRM-IDA-EPI) mode, and quantified by solvent standard internal standard method. The limits of detection were 0.05-0.5 μg/kg and the limits of quantification were 0.2-2 μg/kg for the six opium alkaloids. The recoveries were in the range of 81.1%-98.6% with the relative standard deviations ranging from 2.9% to 15.7% (n=6). The method is sensitive and accurate, and has been successfully applied to the detection of pericarpium papaveris illegally added in foods.
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沈阳化工大学材料科学与工程学院沈阳 110142