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Citation: YI Tinghui, TANG Bobin, ZOU Yun, XI Cunxian, WANG Guomin. Rapid determination of spirotetramat and its metabolite residues in milk by ultra performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2017, 35(7): 677-682. doi: 10.3724/SP.J.1123.2017.03009 shu

Rapid determination of spirotetramat and its metabolite residues in milk by ultra performance liquid chromatography-tandem mass spectrometry

YI Tinghui ^1, ,
TANG Bobin ² ,
ZOU Yun ³ ,
XI Cunxian ² ,
WANG Guomin ²

1.
Chongqing Agricultural Ecological Environment & Resources Protection Station, Chongqing 401121, China;
2.
Chongqing Entry-Exit Inspection and Quarantine Bureau, Chongqing Engineering Technology Research Center of Import and Export Food Safety, Chongqing 400020, China;
3.
Chongqing Municipal & Environmental Sanitation Monitoring Department, Chongqing 401121, China

Received Date: 8 March 2017

Fund Project: Entry-Exit Inspection and Quarantine Trade Standard Item of Certification and Accreditation Administration (No.2014B086).

A method for the rapid and simultaneous determination of spirotetramat (BYI08330) and its four metabolites in milk was developed with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The samples were extracted with acetonitrile for precipitating proteins, degreased with hexane, and analyzed by UPLC-MS/MS in positive electrospray ionization and multiple reaction monitoring (MRM) mode. Good linear relationships between peak areas and mass concentrations of the analytes were obtained in the range of 0.5-50 μ g/L with correlation coefficients greater than 0.998 (n=6). The limits of detection (LODs, S/N=3) and limits of quantification (LOQs, S/N=10) were 0.05-0.30 μ g/L and 0.17-1.00 μ g/L, respectively. The recoveries at the spiked levels of 1.0, 2.0 and 10 μ g/L were in the range of 80.0%-108.8% with relative standard deviations (RSDs) of 4.8%-15.2% (n=6). The method is fast, sensitive and accurate, and can be used to simultaneously determine BYI08330 and its four metabolites in milk.
- ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS),
- spirotetramat (BYI08330),
- metabolites,
- milk
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