Citation: TIAN Huajun, XUE Yun, CHEN Qiaomei, WANG Yan, YAN Chao. Synthesis of AAPBA@KCC-1 and its application in the analysis of sialic acid and gangliosides in serum[J]. Chinese Journal of Chromatography, ;2017, 35(5): 473-481. doi: 10.3724/SP.J.1123.2017.01025 shu

Synthesis of AAPBA@KCC-1 and its application in the analysis of sialic acid and gangliosides in serum

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

Received Date: 20 January 2017

Fund Project: Shanghai Science and Technology Commission Scientific Research Project (Nos. 15142200200, 16142200300)

A new material AAPBA@KCC-1 was synthesized by using 3-acrylamidophenylboronic acid (AAPBA) modified on mesoporous silica KCC-1. First, AAPBA was modified on the surface of KCC-1 by three-step synthesis method. Then, AAPBA@KCC-1 was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), N₂ adsorption-desorption isotherm and X-ray photoelectron spectroscopy (XPS). AAPBA@KCC-1 was used as the dispersive solid-phase extraction (dSPE) adsorbent to extract and enrich sialic acid and ganglioside (GLS) from serum samples. Finally, Fourier transform ion cyclotron resonance mass spectrometry (FT-MS) and ultra performance liquid chromatography-ion mobility spectrometry-quadrupole time of flight mass spectrometry (UPLC-IMS-QTOF MS) were used to evaluated the adsorption ability of AAPBA@KCC-1 to sialic acid and GLS, respectively. The results showed that AAPBA@KCC-1 can effectively adsorb sialic acid and GLS, and can be used for further studies of sialic acid and GLS in biological samples.
- dispersive solid-phase extraction (dSPE),
- mesoporous silica KCC-1,
- 3-acrylamidophenylboronic acid (AAPBA),
- N-acetylneuraminic acid (Neu5Ac),
- sialic acid,
- ganglioside (GLS)
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