Citation: CHEN Lingfan, SHAN Yichu, ZHANG Lihua, ZHANG Yukui. Progress in strategies for enrichment of proteome terminal peptides[J]. Chinese Journal of Chromatography, ;2017, 35(3): 229-236. doi: 10.3724/SP.J.1123.2016.10040 shu

Progress in strategies for enrichment of proteome terminal peptides

1.
Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 18 October 2016

Fund Project: National Natural Science Foundation of China (Nos. 21475127, 21235005)

Termini of proteins are not only the origin and destination of protein synthesis, but also participating in and mediating a host of physiological functions of proteins. The determination of proteins termini provides valuable information for protein structure and function annotation, and helps the profiling of proteases substrates and cleavage sites. Herein, the progress in the strategies for enrichment of protein terminus is reviewed. In the meantime, the applications of terminome analysis for the identification of protease substrate and cleavage site are briefly introduced. Finally, the future of terminome research is discussed.
- terminome,
- termini enrichment,
- protease substrate and cleavage site,
- review
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1.
沈阳化工大学材料科学与工程学院沈阳 110142