Citation: LIANG Chao, QIAO Junqin, HAN Yiyuan, LIAN Hongzhen. Determination of n-octanol/water partition coefficient by reversed-phase high performance liquid chromatography with cholesteryl-bonded phase[J]. Chinese Journal of Chromatography, ;2016, 34(12): 1240-1249. doi: 10.3724/SP.J.1123.2016.09002 shu

Determination of n-octanol/water partition coefficient by reversed-phase high performance liquid chromatography with cholesteryl-bonded phase

1.
School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China;
2.
Center of Modern Analysis, Nanjing University, Nanjing 210093, China

Received Date: 31 August 2016

Fund Project: National Natural Science Foundation of China (Nos. 21275069, 21577057).

Retention behaviors of neutral and weak acidic compounds were studied systematically on a novel cholesteryl-bonded phase column. The relationships between retention factor (k) with volume fraction of organic modifier (φ) were established for each compound with methanol and acetonitrile as organic modifiers. The values of log k_w corresponding to 100% water as mobile phase were obtained by extrapolating procedure. Models of the logarithm of n-octanol/water partition coefficient (log K_ow) versus log k_φ (log k_w) with different mobile phases were established. The values of log k_w of some compounds were predicted with validated models. The results indicated that methanol as organic modifier was more suitable for determination of log K_ow with cholester columns than acetonitrile. For neutral or acidic compounds in neutral forms, the values of log k_w could be predicted with log k_φ from mobile phases with any volume fraction of methanol; for acidic compounds ionized in the mobile phases, the values of log k_w were predicted with the extrapolated log k_w values. Comparison of log K_ow-log k_φ models established on cholester columns in this work with those established on C₁₈ and C₈ columns from the references indicated that it exists special interactions between compounds and the cholesteryl-bonded phase, which deserves further study.
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沈阳化工大学材料科学与工程学院沈阳 110142