Citation: YI Fang, HUANG Xiangyi, REN Jicun. Recent advances in capillary electrophoresis coupled with chemiluminescence detection[J]. Chinese Journal of Chromatography, ;2017, 35(1): 110-120. doi: 10.3724/SP.J.1123.2016.08043 shu

Recent advances in capillary electrophoresis coupled with chemiluminescence detection

School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiaotong University, Shanghai 200240, China

Received Date: 31 August 2016

Fund Project: National Natural Science Foundation of China (Nos. 21075081, 21135004)

Capillary electrophoresis (CE) is considered as a powerful method in many fields, such as biopharmaceuticals, environmental, food and public security analysis, owing to its high separation efficiency. However, the injection of small sample volumes and the short optical length lead to limited sensitivity. So it is necessary to couple with high sensitivity detector to realize the low concentration sample analysis. Chemiluminescence (CL) detection is characterized by providing low background with excellent sensitivity. By coupling with CL, both the high separation efficiency of CE and the high sensitivity of CL can be achieved at the same time. So far, this method has been widely applied to chemical analysis, drug screening, and environment monitoring. In this review, we briefly introduce some developments for CE-CL systems, and then put the emphasis on the applications in the past decades. Moreover, we discuss the perspectives of CE-CL system.
- capillary electrophoresis (CE),
- chemiluminescence (CL) detection,
- review
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