Citation: WANG Weiwei, LIU Suqin, XUE Yun, WANG Yan, YAN Chao. Research progress of aptamer application in solid phase extraction technique[J]. Chinese Journal of Chromatography, ;2017, 35(1): 99-104. doi: 10.3724/SP.J.1123.2016.08033 shu

Research progress of aptamer application in solid phase extraction technique

School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

Received Date: 29 August 2016

Fund Project: Research and Development Program of Shanghai Municipal Science and Technology Commission (No. 15142200200)

Aptamers are short single-stranded oligonucleotides within randomly synthesized nucleic acid libraries by a systematic evolution of ligands by exponential enrichment. Because of specific identification for target molecule, solid phase extraction technique based on aptamers exhibits great potential for extraction, separation, purification and enrichment of trace-target analytes from complex samples, and it attracts more and more attention. This article brings a comprehensive survey of recent developments of solid phase extraction techniques based on aptamers, including the preparation of aptamer-based sorbents, the solid phase extraction procedure and the applications of aptamer-based solid phase extraction. Limits and prospects for aptamer-based solid phase extraction are also discussed.
- solid phase extraction (SPE),
- sample pretreatment,
- affinity adsorption,
- aptamer,
- complex sample,
- review
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