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Citation: JIN Juhua, YE Mingli. Determination of chloride and trifluoroacetate in water- insoluble pharmaceuticals by valve switch-ion chromatography[J]. Chinese Journal of Chromatography, ;2016, 34(10): 960-963. doi: 10.3724/SP.J.1123.2016.07033 shu

Determination of chloride and trifluoroacetate in water- insoluble pharmaceuticals by valve switch-ion chromatography

JIN Juhua ^1, ,
YE Mingli ²

1.
Tongde Hospital of Zhejiang Province, Hangzhou 310028, China;
2.
Chemistry Department of Zhejiang University, Hangzhou 310028, China

Received Date: 26 July 2016

A method was developed for the determination of chloride and trifluoroacetate in water-insoluble pharmaceuticals such as cefixime, lauroyl-indapamide, budesonide by valve switch-ion chromatography. Chromatographic separation was performed on an IonPac AS23 column, 3.5 mmol/L sodium carbonate and 1.0 mmol/L sodium bicarbonate eluents were used. The effects of the types of column and eluent, eluent concentration of inorganic anions were investigated. The linear ranges of the method for seven anions were 0.10-10.00 mg/L, and the detection limits (S/N=3) of chloride and trifluoroacetate were 0.006 mg/L and 0.06 mg/L respectively. The recoveries of inorganic anions spiked in cefixime were between 90% and 94%. The method was successfully used in the determination of inorganic anions in real samples.
- ion chromatography (IC),
- chloride,
- trifluoroacetate,
- water-insoluble pharmaceuticals
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