Citation: YIN Fangchao, WEN Hui, ZHU Guoli, QIN Jianhua. Advances of Caenorhabditis elegans research on microfluidic device[J]. Chinese Journal of Chromatography, ;2016, 34(11): 1031-1042. doi: 10.3724/SP.J.1123.2016.07017 shu

Advances of Caenorhabditis elegans research on microfluidic device

YIN Fangchao ^1,2, ,
WEN Hui ¹ ,
ZHU Guoli ¹ ,
QIN Jianhua ¹

1.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
2.
University of Chinese Academy of Sciences, Beijing 100039, China

Received Date: 14 July 2016

Fund Project: National Natural Science Foundation of China (No. 81273483).

The nematode Caenorhabditis elegans (C. elegans) has been widely used as a multicellular organism for biological research due to its simplicity, short life cycle, and relevance to human genetics and biology. In the past decade, microfluidics technology was emerging as a promising platform for the study of C. elegans both in continuous flow-based or droplet-based format. Worm long-term culture, immobilization, sorting, stimuli exposure and individual worm encapsulation have been realized on microfluidic platform. By providing unique capabilities with precise manipulations and controlled microenvironment, this platform has been used for the study of neurobiology, behaviors, aging and development, and drug screening in C. elegans. In this review, we highlight the recent advances of microfluidic technology in worm manipulations and its biomedical applications. The prospects and challenges of microfluidic technology for future studies are discussed as well.
- microfluidics,
- Caenorhabditis elegans (C. elegans),
- droplets,
- review
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