Citation: SUN Yuming, LI Ying, WANG Yueyue, ZHANG Hua, WANG Yulin. Structure characterization of the degradation products of terazosin hydrochloride[J]. Chinese Journal of Chromatography, ;2016, 34(5): 490-497. doi: 10.3724/SP.J.1123.2015.12006 shu

Structure characterization of the degradation products of terazosin hydrochloride

SUN Yuming ¹ ,
LI Ying ¹ ,
WANG Yueyue ¹ ,
ZHANG Hua ¹ ,
WANG Yulin ^2,,

1.
1. School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China;
2.
2. Basic Medical College, Dalian Medical University, Dalian 116044, China

Corresponding author: WANG Yulin,
Received Date: 7 December 2015

Terazosin hydrochloride is a selective α₁-adrenergic blocker used in the treatment of hypertension and benign prostatic hyperplasia. A high performance liquid chromatography-multistage mass spectrometry with high resolution (HPLC-HRMSⁿ) method was used to detect and identify the degradation products of terazosin hydrochloride treated under stressed oxidation condition. There were 15 degradation products detected. Seven of them were the same as those found in the related references, and the other eight of them were newly found and identified. The main degradation pathways are the hydrolysis of amide bond, hydroxylation, carbonylation and secondary degradation pathways by the combination of the above three ways.
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