Citation: GUO Ming, YU Feng, JIA Keling, LI Jiao, SUN Hai. Determination of tetracycline antibiotics in environmental water using magnetic solid phase extraction combined with high performance liquid chromatography- tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2016, 34(4): 407-413. doi: 10.3724/SP.J.1123.2015.11038 shu

Determination of tetracycline antibiotics in environmental water using magnetic solid phase extraction combined with high performance liquid chromatography- tandem mass spectrometry

1.
Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China

Corresponding author: YU Feng,
Received Date: 23 November 2015

Fund Project: 浙江省公益性技术应用研究(分析测试)项目(2014C37090). (分析测试)项目(2014C37090)

A method has been developed for the simultaneous determination of tetracycline antibiotics in environmental water by magnetic solid phase extraction and high performance liquid chromatography-tandem mass spectrometry. Several important parameters affecting the magnetic solid phase extraction procedure have been optimized for the best recovery. The eluate was analyzed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) under multiple reaction monitoring (MRM) mode with a ZORBAX Eclipse Plus C₁₈ column. Under the optimized conditions, the six tetracycline antibiotics (4-epitetracycline, oxytetracycline, tetracycline, demclocycline, chlortetracycline, anhydrotetracycline) showed good linearities in the range of 1-100 μg/L with the correlation coefficients of 0.9967-0.9993. The limits of detection (LODs) were in the range of 2.44 ng/L to 25.21 ng/L. The spiked recoveries were 80.6%-90.0%. The intra-day relative standard deviations (RSDs) were 0.6%-2.5%, while the inter-day RSDs were 1.1%-7.1%. The method has low background and high sensitivity. It was successfully applied to the simultaneous determination of the six trace tetracycline antibiotics in environmental water.
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