Citation: YANG Sandong, TANG Tao, LI Tong, WANG Fengyun, HAO Qingli. Research development of designing flow cells for optical absorption detectors[J]. Chinese Journal of Chromatography, ;2016, 34(2): 130-139. doi: 10.3724/SP.J.1123.2015.11005 shu

Research development of designing flow cells for optical absorption detectors

YANG Sandong ^1,2 ,
TANG Tao ^1,2 ,
LI Tong ^2,, ,
WANG Fengyun ¹ ,
HAO Qingli ¹

1.
1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;
2.
2. Dalian Elite Analytical Instruments Co., Ltd., Dalian 116023, China

Corresponding author: LI Tong,
Received Date: 9 October 2015

Fund Project: National Key Scientific Instrument and Equipment Development Projects (Grant No. 2012YQ12004401). (Grant No. 2012YQ12004401)

The optical absorption detector is one of the most commonly used detectors for high performance liquid chromatography (HPLC). As a core part of this kind of detector, the designs of flow cells, where light passes through samples for acquiring samples information, will affect the performance of a detector. In order to enhance the signal to noise ratio of detectors and reduce the bands broadening that come from flow cells, it is necessary to design a flow cell with a longer optical path length and a less cell volume while maintaining the luminous flux. However the limitations of the machining capacity make it difficult to increase the optical path length, reduce the cell volume and keep or increase the luminous flux simultaneously. It is a challenge to optimize the designing and machining of flow cells so as to improve the performance of detectors. This review discusses the development of designing flow cells based on the detection principle in some aspects of increasing the optical path length, reducing the cell volume, taking the advantages of total reflection and so on. At the same time, some of the designs are illustrated in detail. These various ideas and structures are significant references for designing flow cells and developing optical absorption detectors.
- high performance liquid chromatography (HPLC),
- optical absorption detector,
- flow cell,
- review
1. [1]
  [1] Ramni K, Navneet K, Ashutosh U, et al. Int Res J Pharm, 2011, 2(5): 1
2. [2]
  [2] Riordon J R. Anal Chem, 2000, 72(18): 483
3. [3]
  [3] Ling C J. Chinese Journal of Chromatography, 1985, 2(5): 263
4. [4]
  [4] Prüβ A, Kempter C, Gysler J, et al. J Chromatogr A, 2003, 1016: 129
5. [5]
  [5] Yang F J. J High Resolut Chromatogr Chromatogr Comm, 1981, 4: 83
6. [6]
  [6] Vindevogel J, Schuddinck G, Dewaele C, et al. J High Resolut Chromatogr Chromatogr Comm, 1988, 11: 317
7. [7]
  [7] Heiger D N, Kaltenbach P, Sievert H J P. Electrophoresis, 1994, 15: 1234
8. [8]
  [8] LI S H. [MS Dissertation]. Nanjing: Nanjing University of Science and Technology, 2009
9. [9]
  [9] Tsuda T, Sweedler J V, Zare R N. Anal Chem, 1990, 62(19): 2149
10. [10]
  [10] Xi X B, Yeung E S. Appl Spectrosc, 1991, 45(7): 1199
11. [11]
  [11] Chervet J P, Soest R E J V, Ursem M. J Chromatogr, 1991, 543: 439
12. [12]
  [12] Wang T S, Aiken J H, Huie C W, et al. Anal Chem, 1991, 63(14): 1372
13. [13]
  [13] Moring S E, Reel R T. Anal Chem, 1993, 65 (23): 3454
14. [14]
  [14] Kim S, Kim W, Hahm J H. J Chromatogr A, 1994, 680: 109
15. [15]
  [15] Lim K, Kim S, Hahn J H. Bull Korean Chem Soc, 2002, 23(2): 295
16. [16]
  [16] Chervet J P, Ursem M, Salzmann J P. J High Resolut Chromatogr, 1989, 12: 278
17. [17]
  [17] Chervet J P. US Patent, 5057216. 1991-10-15
18. [18]
  [18] Chervet J P, Van Soest R E J. US Patent, 5423513. 1995-06-13
19. [19]
  [19] Tsunoda K, Nomura A, Yamada J, et al. Anal Sci, 1988, 4: 321
20. [20]
  [20] Chervet J P, Ursem M. Anal Chem, 1996, 68(9): 1507
21. [21]
  [21] Dai C S, Liu T, Zhai F, et al. China Patent, 201220611696.8. 2013-4-24
22. [22]
  [22] Zhang X H, Chen G L, Shang D F, et al. Journal of Instrumental Analysis, 2007, 26(2): 261
23. [23]
  [23] Bui D A, Bomastyk B, Hauser P C. J Sep Sci, 2013, 36: 3152
24. [24]
  [24] Sharma S, Plistil A, Simpson R S, et al. J Chromatogr A, 2014, 1327: 80
25. [25]
  [25] Sestak J, Moravcova D, Kahle V. J Chromatogr A, 2015, 1421: 2
26. [26]
  [26] Sharma S, Tolley L T, Tolley H D, et al. J Chromatogr A, 2015, 1421: 38
27. [27]
  [27] Nazario C E, Silva M R, Franco M S, et al. J Chromatogr A, 2015, 1421: 18
28. [28]
  [28] Enami T, Nagae N. Am Lab, 1998(24): 29
29. [29]
  [29] Aiello M, Mclaren R. Anal Chem, 2001, 73(6): 1387
30. [30]
  [30] Xu C F, Zhang S Y, Fan H Z, et al. Acta Chimica Sinica, 2000, 58(8): 1022
31. [31]
  [31] Shen H L, Xu C F, Huang Z Y, et al. Chinese Journal of Analytical Chemistry, 2003, 31(6): 755
32. [32]
  [32] Wang H, Yi E C, Ibarra C A, et al. Analyst, 2000, 125(6): 1061
33. [33]
  [33] Doehl J, Greibrokk T. J Chromatogr Sci, 1987, 25: 99
34. [34]
  [34] Walrafen G E, Stone J. Appl Spectrosc, 1972, 26(6): 585
35. [35]
  [35] Yang M K. J Micro-Nanolith Mem, 2008, 7(3): 033010
36. [36]
  [36] Sun Z H, Zhou W, Xu Z T, et al. Spectrosc Spect Anal, 2011, 31(11): 2881
37. [37]
  [37] Waterbury R D, Yao W S, Byrne R H. Anal Chim Acta, 1997, 357: 99
38. [38]
  [38] Yao W S, Byrne R H. Talanta, 1999, 48: 277
39. [39]
  [39] Duggan M P, Mccreedy T, Aylott J W. Analyst, 2003, 128(11): 1336
40. [40]
  [40] Du W B, Fang Q, Fang Z L. Chemical Journal of Chinese University, 2004, 25(4): 610
41. [41]
  [41] Du W B, Fang Q, He Q H, et al. Anal Chem, 2005, 77(5): 1330
42. [42]
  [42] Villena G, Bejan I, Kurtenbach R, et al. Atmos Meas Tech, 2011, 4(8): 1663
43. [43]
  [43] Yang Q H, Gan W E, Sun H H. Journal of Instrumental Analysis, 2011, 30(2): 199
44. [44]
  [44] Deland P. Am Lab, 1997(22): 19
45. [45]
  [45] Cohen S, Murphy B J. Am Lab, 1999(6): 28
46. [46]
  [46] Febre D L. Europe Patent, 0089157 A1. 1983-09-21
47. [47]
  [47] Liu S Y. US Patent, 5444807. 1995-08-22
48. [48]
  [48] Gilby A C, Carson W W. US Patent, 5184192. 1993-02-02
49. [49]
  [49] Dourdeville T A, Gilby A C. WO Patent, 00/48023. 2000-08-17
50. [50]
  [50] Jeannotte A, Gilby A C, Dourdeville T, et al. WO Patent, 2006/023525 A1. 2006-03-02
51. [51]
  [51] Jeannotte A, Leveille M J, Denecke F. WO Patent, 2009/143217 A1. 2009-11-26
52. [52]
  [52] Garrett M H. Canada Patent, 2355453C. 2009-08-18
53. [53]
  [53] Mueller J, Mueller B. US Patent, 7005090B2. 2006-02-28
54. [54]
  [54] Kheim T. Europe Patent, 2124036A1. 2009-11-25
55. [55]
  [55] Kraiczek K, Mannion J, Killeen K P. US Patent, 20140373606A1. 2014-12-25
56. [56]
  [56] Gooijer C, Hoornweg G P, Beer T D, et al. J Chromatogr A, 1998, 824: 1
57. [57]
  [57] Munk M N. US Patent, 5608517. 1997-03-04
58. [58]
  [58] Gilby A C. WO Patent, 03/073069 A1. 2003-09-04
59. [59]
  [59] Liu Z G, Zhang Y H, Han G F, et al. China Patent, 201010235405.5. 2012-02-01
60. [60]
  [60] Gilby A C, Deluca J M. WO Patent, 99/02968. 1999-01-21
61. [61]
  [61] Brooker G. Anal Chem, 1971, 43(8): 1095
62. [62]
  [62] Abbas A A, Shelly D C. Anal Chim Acta, 1999, 397: 191
1. [1]
  .
  CCS Chemistry 综述推荐│绿色氧化新思路：光/电催化助力有机物高效升级
  . CCS Chemistry, 2025, 7(10.31635/ccschem.024.202405369): -.
2. [2]
  Mengyao Shi , Kangle Su , Qingming Lu , Bin Zhang , Xiaowen Xu . Determination of Potassium Content in Tobacco Stem Ash by Flame Atomic Absorption Spectroscopy. University Chemistry, 2024, 39(10): 255-260. doi: 10.12461/PKU.DXHX202404105
3. [3]
  Di Yang , Jiayi Wei , Hong Zhai , Xin Wang , Taiming Sun , Haole Song , Haiyan Wang . Rapid Detection of SARS-CoV-2 Using an Innovative “Magic Strip”. University Chemistry, 2024, 39(4): 373-381. doi: 10.3866/PKU.DXHX202312023
4. [4]
  Qilong Fang , Yiqi Li , Jiangyihui Sheng , Quan Yuan , Jie Tan . Magical Pesticide Residue Detection Test Strips: Aptamer-based Lateral Flow Test Strips for Organophosphorus Pesticide Detection. University Chemistry, 2024, 39(5): 80-89. doi: 10.3866/PKU.DXHX202310004
5. [5]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
6. [6]
  Yang YANG , Pengcheng LI , Zhan SHU , Nengrong TU , Zonghua WANG . Plasmon-enhanced upconversion luminescence and application of molecular detection. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 877-884. doi: 10.11862/CJIC.20230440
7. [7]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
8. [8]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
9. [9]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
10. [10]
  Tongyu Zheng , Teng Li , Xiaoyu Han , Yupei Chai , Kexin Zhao , Quan Liu , Xiaohui Ji . A DIY pH Detection Agent Using Persimmon Extract for Acid-Base Discoloration Popularization Experiment. University Chemistry, 2024, 39(5): 27-36. doi: 10.3866/PKU.DXHX202309107
11. [11]
  Qin Tu , Anju Tao , Tongtong Ma , Jinyi Wang . Innovative Experimental Teaching of Escherichia coli Detection Based on Paper Chip. University Chemistry, 2024, 39(6): 271-277. doi: 10.3866/PKU.DXHX202309062
12. [12]
  Jinghan ZHANG , Guanying CHEN . Progress in the application of rare-earth-doped upconversion nanoprobes in biological detection. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2335-2355. doi: 10.11862/CJIC.20240249
13. [13]
  Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002
14. [14]
  Hao BAI , Weizhi JI , Jinyan CHEN , Hongji LI , Mingji LI . Preparation of Cu₂O/Cu-vertical graphene microelectrode and detection of uric acid/electroencephalogram. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1309-1319. doi: 10.11862/CJIC.20240001
15. [15]
  Kuaibing Wang , Honglin Zhang , Wenjie Lu , Weihua Zhang . Experimental Design and Practice for Recycling and Nickel Content Detection from Waste Nickel-Metal Hydride Batteries. University Chemistry, 2024, 39(11): 335-341. doi: 10.12461/PKU.DXHX202403084
16. [16]
  Li'na ZHONG , Jingling CHEN , Qinghua ZHAO . Synthesis of multi-responsive carbon quantum dots from green carbon sources for detection of iron ions and L-ascorbic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 709-718. doi: 10.11862/CJIC.20240280
17. [17]
  Junjie Zhang , Yue Wang , Qiuhan Wu , Ruquan Shen , Han Liu , Xinhua Duan . Preparation and Selective Separation of Lightweight Magnetic Molecularly Imprinted Polymers for Trace Tetracycline Detection in Milk. University Chemistry, 2024, 39(5): 251-257. doi: 10.3866/PKU.DXHX202311084
18. [18]
  Qin Hou , Jiayi Hou , Aiju Shi , Xingliang Xu , Yuanhong Zhang , Yijing Li , Juying Hou , Yanfang Wang . Preparation of Cuprous Iodide Coordination Polymer and Fluorescent Detection of Nitrite: A Comprehensive Chemical Design Experiment. University Chemistry, 2024, 39(8): 221-229. doi: 10.3866/PKU.DXHX202312056
19. [19]
  Liwei Wang , Guangran Ma , Li Wang , Fugang Xu . A Comprehensive Analytical Chemistry Experiment: Colorimetric Detection of Vitamin C Using Nanozyme and Smartphone. University Chemistry, 2024, 39(8): 255-262. doi: 10.3866/PKU.DXHX202312094
20. [20]
  Yongzhi LI , Han ZHANG , Gangding WANG , Yanwei SUI , Lei HOU , Yaoyu WANG . A two-dimensional metal-organic framework for the determination of nitrofurantoin and nitrofurazone in aqueous solution. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 245-253. doi: 10.11862/CJIC.20240307

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(372)
HTML views(36)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142