Citation: ZHANG Qianchun, LUO Xialin, LI Gongke, XIAO Xiaohua. Progress in sample preparation and analytical methods for trace polar small molecules in complex samples[J]. Chinese Journal of Chromatography, ;2015, 33(9): 904-909. doi: 10.3724/SP.J.1123.2015.08012 shu

Progress in sample preparation and analytical methods for trace polar small molecules in complex samples

ZHANG Qianchun ^1,2 ,
LUO Xialin ¹ ,
LI Gongke ^1,, ,
XIAO Xiaohua ^1,,

1.
1. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China;

Corresponding author: LI Gongke, XIAO Xiaohua,
Received Date: 10 August 2015

Fund Project: 国家自然科学基金项目(21127008) (21127008)高等学校博士学科点专项基金项目(20120171110001). (20120171110001)

Small polar molecules such as nucleosides, amines, amino acids are important analytes in biological, food, environmental, and other fields. It is necessary to develop efficient sample preparation and sensitive analytical methods for rapid analysis of these polar small molecules in complex matrices. Some typical materials in sample preparation, including silica, polymer, carbon, boric acid and so on, are introduced in this paper. Meanwhile, the applications and developments of analytical methods of polar small molecules, such as reversed-phase liquid chromatography, hydrophilic interaction chromatography, etc., are also reviewed.
- complex samples,
- sample preparation,
- polar small molecule,
- analytical method,
- review
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