Citation: LIN Tao, FAN Jianlin, LIU Xingyong, CHEN Xinglian, LI Yangang, LIU Hongcheng. Determination of amantadine and rimantadine residues in egg and chicken samples by dispersive solid phase extraction purification-ultra high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2015, 33(11): 1169-1174. doi: 10.3724/SP.J.1123.2015.08010 shu

Determination of amantadine and rimantadine residues in egg and chicken samples by dispersive solid phase extraction purification-ultra high performance liquid chromatography-tandem mass spectrometry

LIN Tao ^1,2 ,
FAN Jianlin ¹ ,
LIU Xingyong ¹ ,
CHEN Xinglian ¹ ,
LI Yangang ¹ ,
LIU Hongcheng ^1,2,,

1.
1. Institute of Quality Standards & Testing Technique, Yunnan Academy of Agricultural Science, Kunming 650223, China;

Corresponding author: LIU Hongcheng,
Received Date: 9 August 2015

Fund Project: 云南省社会发展科技计划项目(2013RA012) (2013RA012)云南省应用基础研究计划青年项目(2013FD064) (2013FD064)云南省科技创新平台建设计划项目(2014DA001). (2014DA001)

A method was developed for the determination of residual amantadine and rimantadine in eggs and chickens by dispersive solid phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry. Egg and chicken samples were extracted with ammonia water-acetonitrile (2 : 98, v/v). The extraction solution was dried to 1 mL under nitrogen, and then purified by dispersive solid phase extraction method with C18 and NH₂ sorbents. After purification, the extraction solution was filtered through a filter. The target compounds were analyzed by ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) on a ZORBAX C18 column using a mixture of 1 mmol/L ammonium acetate solution (containing 0.1% (v/v) formic acid) and methanol as mobile phases with gradient elution. The mass spectrometer was operated under multiple reaction monitoring (MRM) mode in positive mode. The good linearities were obtained for amantadine and rimantadine at a concentration range of 0.15-10.0 μ g/L. The limits of detection for amantadine and rimantadine were all 0.05 μ g/kg, and the limits of quantification were 0.20 μ g/kg. The recoveries of amantadine and rimantadine in eggs and chickens at three spiked levels (0.2, 1.0 and 2.0 μ g/kg) were in the range of 89%-108% with the relative standard deviations of 5.0%-8.6%. The results demonstrated that the method is suitable for the determination of amantadine and rimantadine in eggs and chickens.
- dispersive solid phase extraction,
- ultra high performance liquid chromatography (UHPLC),
- tandem mass spectrometry (MS/MS),
- amantadine,
- rimantadine,
- eggs,
- chickens
1. [1]
  [1] Liu D, Fan Z C, Zhang Y, et al. China Pharmacist (刘丹, 范子宸, 张瑛, 等. 中国药师), 2009, 12(11): 1640
2. [2]
  [2] Gao Z, Wang Y, Su X M, et al. Guangzhou Chemistry (高治, 王艳, 苏晓明, 等. 广州化学), 2004, 29(4): 59
3. [3]
  [3] Ai L F, Ma Y S, Chen R C, et al. Chinese Journal of Analytical Chemistry (艾连峰, 马育松, 陈瑞春, 等. 分析化学), 2013, 41(8): 1194
4. [4]
  [4] Chen Y W, Shieh J P, Chen Y C, et al. Eur J Pharmacol, 2012, 693(1/2/3): 25
5. [5]
  [5] Guay D R P. Drugs & Aging, 1994, 5(1): 8
6. [6]
  [6] Lou Y J, Chen S, Tao Q F. Chinese Journal of Pharmaceutical Analysis (楼永军, 陈爽, 陶巧凤. 药物分析杂志), 2011, 31(3): 493
7. [7]
  [7] Rakestraw D. J Pharm Biomed Anal, 1993, 11(8): 699
8. [8]
  [8] Zhang L Y, Wang K, Qian Y X. Chinese Journal of Pharmaceutical Analysis (张芦燕, 王坤, 钱一鑫. 药物分析杂志), 2012, 32(1): 159
9. [9]
  [9] Higashi Y, Uemori I, Fujii Y. Biomed Chromatogr, 2005, 19(9): 655
10. [10]
  [10] Cao Y F, Kang J, Chang Q Y, et al. Chinese Journal of Chromatography (曹亚飞, 康健, 常巧英, 等. 色谱), 2015, 33(2): 132
11. [11]
  [11] Meng X, Xie S H, Xie S T, et al. Journal of Analytical Science (孟霞, 谢世红, 谢世涛, 等. 分析科学学报), 2015, 31(2): 208
12. [12]
  [12] Peng X T, Hu X Z, Shen J, et al. Journal of Analytical Science (彭西甜, 胡西洲, 沈菁, 等. 分析科学学报), 2014, 30(4): 572
13. [13]
  [13] Arndt T, Guessregen B, Hohl A, et al. Clin Chim Acta, 2005, 359(1/2): 125
14. [14]
  [14] Zhao S, Li D, Qiu J, et al. Anal Methods, 2014, 6(17): 7062
15. [15]
  [15] Li N, Zhang Y T, Liu L, et al. Chinese Journal of Chromatography (李娜, 张玉婷, 刘磊, 等. 色谱), 2014, 32(12): 1313
16. [16]
  [16] Yun H, Cui F Y, Yan H, et al. Chinese Journal of Chromatography (云环, 崔凤云, 严华, 等. 色谱), 2013, 31(8): 724
17. [17]
  [17] Chen H H, Wei M Y, Zhou W, et al. Journal of Chinese Mass Spectrometry Society (陈慧华, 韦敏珏, 周炜, 等. 质谱学报), 2013, 34(4): 226
18. [18]
  [18] Yi X B, Qiu L Q, Liu S Q, et al. Journal of Instrumental Analysis (易锡斌, 裘立群, 刘世琦, 等. 分析测试学报), 2015, 34(3): 346
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