Citation: ZHOU Sunying, CHEN Jinyun, TAN Jingjing, LIN Xucong, XIE Zenghong. Preparation of octadecyl methacrylate-based polymer stationary phase by in-situ polymerization for open tubular capillary electrochromatography[J]. Chinese Journal of Chromatography, ;2015, 33(12): 1307-1313. doi: 10.3724/SP.J.1123.2015.07010 shu

Preparation of octadecyl methacrylate-based polymer stationary phase by in-situ polymerization for open tubular capillary electrochromatography

1.
1. School of Pharmacy, Fujian Medical University, Fuzhou 350108, China;

Corresponding author: ZHOU Sunying,
Received Date: 9 July 2015

Fund Project: 福建省自然科学基金项目(2013J01037). (2013J01037)

The preparation of porous polymethacrylate-based open tubular capilary columns by in-situ copolymerization of octadecyl methacrylate (OMA), and ethylene dimethacrylate (EDMA) in N,N-dimethylformamide (DMF) solvent are proposed. The parameters of the preparation procedure of the stationary phase are discussed in detail. The surface of the cross-section of an open tubular (OT) column by scanning electron microscope (SEM) showed wrinkle configuration, which is expedient to enhance proportion of stationary phase and column capacity. Efficient separation of six alkyl benzene homologous series (namely, toluene, ethylbenzene, propylbenzene, butylbenzene, amylbenzene and hexylbenzene) were performed by CEC using the prepared column, and their elution order was in agreement with their hydrophobicity. So, the OT columns bonded with octadecyl ligands yielded reversed-phase retention behavior toward nonpolar solutes. In addition, the separation of four antiepileptics was also investigated with satisfactory effectiveness. The column efficiency range was 35300-49800 plates/m. The results showed that the C₁₈-OT column of organic matrix for reversed-phase chromatography was successfully prepared via in-situ polymerization in this work. Hereby, this new column thus offers a promising new alternative in OT-CEC and will be useful in separation science.
- in-situ polymerization,
- stationary phase,
- octadecyl methacrylate (OMA),
- open tubular capillary electrochromatography (OT-CEC),
- antiepileptics
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沈阳化工大学材料科学与工程学院沈阳 110142