Citation: SHI Xueyan, LIU Feipeng, BIAN Qinghua. Enantioseparation of 2-phenylcarboxylic acid esters by capillary gas chromatography[J]. Chinese Journal of Chromatography, ;2016, 34(1): 85-88. doi: 10.3724/SP.J.1123.2015.06044 shu

Enantioseparation of 2-phenylcarboxylic acid esters by capillary gas chromatography

1.
1. College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China;
2.
2. College of Science, China Agricultural University, Beijing 100193, China

Corresponding author: SHI Xueyan,
Received Date: 24 June 2015

Fund Project: 公益性行业(农业)科技专项(201303027). (农业)科技专项(201303027)

Chiral 2-arylcarboxylic acid derivatives are important intermediates for preparing 2-arylcarboxylic acids, which are non-steroidal anti-inflammatory drugs (NSAIDs). In order to separate 2-phenylcarboxylic acid ester enantiomers by capillary gas chromatography (CGC), 2,6-di-O-pentyl-3-O-butyryl- β-cyclodextrin and 2,6-di-O-benzyl-3-O-heptanoyl- β-cyclodextrin were used as CGC chiral stationary phases, separately, and their enantioseparation abilities to enantiomers of methyl 2-phenylbutanoate, ethyl 2-phenylbutanoate, isopropyl 2-phenylbutanoate, methyl 2-phenylpropionate and cyclopentyl 2-phenylpropionate were examined. It was found that methyl 2-phenylbutanoate, methyl 2-phenylpropionate and cyclopentyl 2-phenylpropionate were successfully separated by using 2,6-di-O-pentyl-3-O-butyryl- β-cyclodextrin and 2,6-di-O-benzyl-3-O-heptanoyl- β-cyclodextrin as CGC chiral stationary phases, respectively. The enantiomer separation abilities of 2,6-di-O-pentyl-3-O-butyryl- β-cyclodextrin to the three pairs of 2-phenylcarboxylic acid esters tested are superior to those of 2,6-di-O-benzyl-3-O-heptanoyl- β-cyclodextrin.
- capillary gas chromatography (CGC),
- β-cyclodextrin derivatives,
- chiral stationary phases,
- 2-phenylcarboxylic acid esters,
- enantiomer separation
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