Citation: XU Jiwei, SUN Yuanshe, TANG Tao, XIA Mingzhu, LEI Wu, WANG Fengyun, LI Tong. State of art of mixed-mode stationary phase[J]. Chinese Journal of Chromatography, ;2015, 33(11): 1140-1146. doi: 10.3724/SP.J.1123.2015.06025 shu

State of art of mixed-mode stationary phase

XU Jiwei ¹ ,
SUN Yuanshe ² ,
TANG Tao ^1,2 ,
XIA Mingzhu ¹ ,
LEI Wu ¹ ,
WANG Fengyun ¹ ,
LI Tong ^2,,

1.
1. Nanjing University of Science and Technology, Nanjing 210094, China;

Corresponding author: LI Tong,
Received Date: 17 June 2015

Fund Project: 国家自然科学基金面上项目(51472121) (51472121)国家重大科学仪器设备开发专项(2012YQ12004401,2012YQ12004403) (2012YQ12004401,2012YQ12004403)

With the development of science and technology, more and more complex samples like peptides and proteins need to be separated. It is difficult to separate them by single mode chromatography. Due to the unique separation character of mixed-mode chromatography, the same separation performance can be obtained in mixed-mode chromatography in one separation as multidimensional chromatography. And some disadvantages of multidimensional chromatography can be avoided in mixed-mode chromatography, such as the complexity of the system, the poor compatibility of mobile phases and the long analytical time. More and more attention is devoted to the mixed-mode chromatography in recent years. The focus on the mixed-mode chromatography is to design new structures of mixed-mode stationary phase. At present, mixed-mode stationary phases included reversed-phase/ion-exchange, reversed-phase/hydrophilic, hydrophilic/ion-exchange, zwitterionic and trimode mixed-mode stationary phases. The kinds of mixed-mode stationary phases are summarized and their features and applications in different fields are discussed in this review.
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