Citation: HU Tingting, QU Xiaoyu, KANG Mingqin, SONG Qinglian, YANG Lu, ZHAO Yunhui, ZHANG Daihui. Rapid screening and confirmation of illegally added anti-impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry[J]. Chinese Journal of Chromatography, ;2015, 33(8): 897-901. doi: 10.3724/SP.J.1123.2015.03020 shu

Rapid screening and confirmation of illegally added anti-impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry

1.
1. Jilin Entry-Exit Inspection and Quarantine Bureau, Changchun 130062, China;

Corresponding author: ZHANG Daihui,
Received Date: 16 March 2015

Fund Project: 国家科技支撑计划项目(2012BAK08B01). (2012BAK08B01)

A method was established for rapid screening and quantifying 11 illegally added anti-impotence preparations (yohimbine, acetildenafil, nor-acetildenafil, homosildenafil, hydroxyhomosildenafil, sildenafil, vardenafil, thioaildenafil, tadalafil, pseudovardenafil, dapoxetine) in health care products by high performance liquid chromatography-high resolution mass spectrometry. The samples were extracted with methanol and analyzed by positive mode in the MS detection. The results showed that the limits of detection were 25.0 ng/mL except for nor-acetildenafil (5.0 ng/mL), the linear ranges were 5.0-200.0 ng/mL except for nor-acetildenafil (25.0-500.0 ng/mL) with the correlation coefficients not less than 0.9990. The recoveries were in the range of 82.0%-105.9% with the relative standard deviations of 4.7%-16.5%. This method is accurate, simple and rapid, and can be used in rapid screening and quantitative analysis of the 11 illegally added anti-impotence in health care products.
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沈阳化工大学材料科学与工程学院沈阳 110142