Citation: GOU Xinlei, ZHAO Xinying, CHI Haitao, GAO Xia, ZHOU Mingqiang, LIU Weili. Simultaneous determination of ten benzotriazole ultraviolet stabilizers in food contact plastic materials by solid phase extraction and ultra performance liquid chromatography with tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2015, 33(6): 571-576. doi: 10.3724/SP.J.1123.2015.03019 shu

Simultaneous determination of ten benzotriazole ultraviolet stabilizers in food contact plastic materials by solid phase extraction and ultra performance liquid chromatography with tandem mass spectrometry

GOU Xinlei ¹ ,
ZHAO Xinying ¹ ,
CHI Haitao ¹ ,
GAO Xia ^1,2 ,
ZHOU Mingqiang ¹ ,
LIU Weili ^1,2,,

1.
1. Beijing Key Laboratory of Detection Technology and Quality Evaluation of Organic Material, Beijing Center for Physical and Chemical Analysis, Beijing 100089, China;

Corresponding author: LIU Weili,
Received Date: 16 March 2015

Fund Project: 北京市自然科学基金项目(2122018) (2122018)北京市科学技术研究院萌芽计划项目(2015-02). (2015-02)

A sensitive method was developed for the simultaneous determination of ten benzotriazole ultraviolet stabilizers in food contact plastic materials by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The sample was extracted by methanol-dichloromethane, and purified by a C18 solid-phase extraction (SPE) column. The separation was performed by using water containing 0.1% (v/v) formic acid and methanol as the mobile phases with gradient elution at a flow rate of 0.3 mL/min. The electrospray ionization (ESI) source in positive ion mode was used for the analysis of the ten benzotriazole ultraviolet stabilizers in multiple reaction monitoring (MRM) mode. The results showed that the standard curves were obtained with good correlation coefficients (r²>0.996) in their linear concentration ranges. The limits of detection (LODs, S/N=3) for the ten benzotriazole ultraviolet stabilizers were in the range of 0.6-1.6 μg/kg. The mean recoveries for the ten benzotriazole ultraviolet stabilizers at three spiked levels (low, medium and high) were 75.2%-85.3% with relative standard deviations of 1.0%-5.7%. Ten kinds of food contact plastic materials were tested, and 2,2'-methylenebis(6-(benzotriazol-2-yl)-4-tert-octylphenol) (UV-360) was found in a sample of polyethylene (PE) material. The method is accurate, simple, rapid and feasible for the simultaneous determination of benzotriazole ultraviolet stabilizers in food plastic materials.
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