Citation: Vanik GHOULIPOUR, Zahra HASSANKHANI-MAJD. Selective separation and determination of isoproterenol on thin layers of bismuth silicate ion-exchanger[J]. Chinese Journal of Chromatography, ;2015, 33(6): 667-671. doi: 10.3724/SP.J.1123.2015.01014 shu

Selective separation and determination of isoproterenol on thin layers of bismuth silicate ion-exchanger

Vanik GHOULIPOUR ^, ,
Zahra HASSANKHANI-MAJD

1.
Faculty of Chemistry, Kharazmi University, Tehran 15719-14911, Iran

Corresponding author: Vanik GHOULIPOUR,
Received Date: 14 January 2015

A simple and sensitive method for the separation and determination of isoproterenol from other doping drugs has been developed on thin layers of bismuth silicate, a synthetic inorganic ion exchanger as adsorbent in thin layer chromatography (TLC). A mixture of methanol and 0.1 mol/L formic acid (3:7, v/v) was employed as the mobile phase. The development time was 32 min. The quantitative measurement were performed with a Camag TLC Scanner-3 at wavelength (λ) of 410 nm. The isoproterenol recovery in this procedure was 98.9%. The linear correlation coefficient was greater than 0.9871 and the relative standard deviation (RSD) was less than 0.94. The limit of detection (LOD) and limit of quantification (LOQ) were 7.7×10^-7mol/L and 3.85 ×10^-6mol/L, respectively. This method has been applied in the determination of isoproterenol in dosage forms and in biological fluids.
- high performance thin layer chromatography (HPTLC),
- inorganic ion-exchanger,
- densitometry
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