Citation: ZHU Weixia, SUN Zhuanlian, YUAN Ping, YANG Jizhou, LIU Yafeng, SUN Wuyong. Determination of poppy ingredients in chafing dish materials by isotopic internal standard coupled with multiple reaction monitoring and online full scan mass spectrometry[J]. Chinese Journal of Chromatography, ;2014, 32(12): 1333-1339. doi: 10.3724/SP.J.1123.2014.09012 shu

Determination of poppy ingredients in chafing dish materials by isotopic internal standard coupled with multiple reaction monitoring and online full scan mass spectrometry

1.
Henan Entry-Exit Inspection and Quarantine Bureau, Zhengzhou 450003, China

Corresponding author: YANG Jizhou,
Received Date: 9 September 2014
Available Online: 30 September 2014
Fund Project: 河南省科技攻关项目(122102110167) (122102110167)质检总局科研项目(2007IK162). (2007IK162)

A confirmative method was developed for determining five poppy alkaloids including morphine, codeine, papaverine, tibane, noscapine in chafing dish ingredients by high performance liquid chromatography coupled with triple quadrupole linear ion trap mass spectrometry (HPLC-Q Trap MS). The sample was extracted with dilute HCl solution under heating condition. The removal of lipid procedure was performed with hexane. The purification was carried out on a mixed-cation solid-phase extraction column (MCX) and ethyl acetate-methanol containing 5% aqueous ammonia was used for elution. A PAK ST column was used to separate the analytes, and 5 mmol/L ammonium acetate methanol and 10 mmol/L ammonium acetate (pH 3.6) were used as mobile phases. The five alkaloids was detected in the positive mode simultaneously by multiple reaction monitoring (MRM) and online enhanced product ion full scan (EPI). The LODs were 0.05-0.5 μg/kg and the LOQs were 0.2-2 μg/kg for the five poppy alkaloids. The overall recoveries of the method varied from 64.2% to 110.6%, and the RSD were between 4.2% and 12.5%. The EPI mass spectra of positive samples were searched through standard library for qualitative confirmation. The detection of real hot pot material samples showed this method can be used for the simple and accurate determination of the five poppy alkaloid residues in chafing dish.
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沈阳化工大学材料科学与工程学院沈阳 110142