Citation: SUN Jing, CAO Ling, FENG Youlong, TAN Li. Application of precursor ion scanning method in rapid screening of illegally added phosphodiesterase-5 inhibitors and their unknown derivatives in Chinese traditional patent medicines and health foods[J]. Chinese Journal of Chromatography, ;2014, 32(11): 1187-1196. doi: 10.3724/SP.J.1123.2014.06015 shu

Application of precursor ion scanning method in rapid screening of illegally added phosphodiesterase-5 inhibitors and their unknown derivatives in Chinese traditional patent medicines and health foods

1.
Jiangsu Institute for Food and Drug Control, Nanjing 210008, China

Received Date: 11 June 2014
Available Online: 23 July 2014
Fund Project: 国家科技支撑计划项目(2012BAK08B02). (2012BAK08B02)

The compounds with similar structure often have similar pharmacological activities. So it is a trend for illegal addition that new derivatives of effective drugs are synthesized to avoid the statutory test. This bring challenges to crack down on illegal addition behavior, however, modified derivatives usually have similar product ions, which allow for precursor ion scanning. In this work, precursor ion scanning mode of a triple quadrupole mass spectrometer was first applied to screen illegally added drugs in complex matrix such as Chinese traditional patent medicines and healthy foods. Phosphodiesterase-5 inhibitors were used as experimental examples. Through the analysis of the structure and mass spectrum characteristics of the compounds, phosphodiesterase-5 inhibitors were classified, and their common product ions were screened by full scan of product ions of typical compounds. Then high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method with precursor ion scanning mode was established based on the optimization of MS parameters. The effect of mass parameters and the choice of fragment ions were also studied. The method was applied to determine actual samples and further refined. The results demonstrated that this method can meet the need of rapid screening of unknown derivatives of phosphodiesterase-5 inhibitors in complex matrix, and prevent unknown derivatives undetected. This method shows advantages in sensitivity, specificity and efficiency, and is worth to be further investigated.
1. [1]
  [1] Sun J, Zhang Z H, Wang W J. Journal of Pharmaceutical Research (孙晶, 张中湖, 王维剑. 药学研究), 2013, 32(3): 174
2. [2]
  [2] Singh S, Prasad B, Savaliya A A, et al. Trac-Trend Anal Chem, 2009, 28(1): 13
3. [3]
  [3] Yu H, Hu Q, Zhang Y, et al. Chinese Pharmaceutical Journal (于泓, 胡青, 张延, 等. 中国药学杂志), 2013, 48(15): 1312
4. [4]
  [4] Wollein U, Eisenreich W, Schramek N. J Pharm Biomed Anal, 2011, 56: 705
5. [5]
  [5] Chen A Z, Wang Z W, Yang Z, et al. Chinese Traditional Patent Medicine (陈安珍, 王尊文, 杨钊, 等. 中成药), 2009, 31(11): 1712
6. [6]
  [6] Zhu L, Ruan L P, Liu H L, et al. Chinese Journal of Chromatography (朱琳, 阮丽萍, 刘华良, 等. 色谱), 2013, 31(7): 709
7. [7]
  [7] Liu C, Xia J, Hu Q, et al. Chinese Traditional Patent Medicine (刘畅, 夏晶, 胡青, 等. 中成药), 2009, 31(9): 1371
8. [8]
  [8] Wang M L, Yan H F, Fu S L, et al. Chinese Journal of Chromatography (王美玲, 颜鸿飞, 傅善良, 等. 色谱), 2012, 30(10): 980
9. [9]
  [9] Xiu X L, Luo X, Niu Z Y, et al. Chinese Journal of Chromatography (修晓丽, 罗忻, 牛增元, 等. 色谱), 2013, 31(10): 961
10. [10]
  [10] Kee C L, Ge X W, Koh H L, et al. J Pharm Biomed Anal, 2012, 70: 265
11. [11]
  [11] Deng K P, Luo Z Y, Lei Y. Chinese Pharmaceutical Journal (邓鲲鹏, 罗卓雅, 雷毅. 中国药学杂志), 2011, 46(18): 1441
12. [12]
  [12] Ge J C, Xu Q X, Yan J, et al. Journal of Chinese Mass Spectrometry Society (葛京城, 许庆轩, 闫静, 等. 质谱学报), 2012, 33(2): 123
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沈阳化工大学材料科学与工程学院沈阳 110142