Citation: LI Pi, BAI Hua, LI Haiyu, CHEN Ming, LÜ Qing, ZHANG Qing. Determination of migration of 15 N-nitrosamines and N-nitrosatable substances from children’s latex articles by gas chromatography-tandem mass spectrometry using solid phase extraction[J]. Chinese Journal of Chromatography, ;2014, 32(1): 81-88. doi: 10.3724/SP.J.1123.2013.08032 shu

Determination of migration of 15 N-nitrosamines and N-nitrosatable substances from children’s latex articles by gas chromatography-tandem mass spectrometry using solid phase extraction

LI Pi ¹ ,
BAI Hua ¹ ,
LI Haiyu ¹ ,
CHEN Ming ² ,
LÜ Qing ¹ ,
ZHANG Qing ^1,,

1.
1. Chinese Academy of Inspection and Quarantine, Beijing 100123, China;

Corresponding author: ZHANG Qing,
Received Date: 19 August 2013
Available Online: 18 September 2013
Fund Project: 国家质检总局科研项目(2011IK114,2012104018) (2011IK114,2012104018)国家质检总局科技支撑课题(2013BAK04B03). (2013BAK04B03)

A method based on gas chromatography-tandem mass spectrometry (GC-MS/MS) using solid phase extraction (SPE) has been developed for the determination of 15 N-nitrosamines from children's latex articles. Artificial saliva was used as the migration solution to extract N-nitrosamines in children's latex articles. And then a polar modified polystyrene-divinylbenzene copolymer (Chromabond Easy) was used for the selective SPE of the analytes in the migration solution. The analytes were then separated on an HP-5MS UI GC column and determined by MS/MS in multiple reaction monitoring mode for qualitative and quantitative analysis. Good linearity ranged from 5 μg/L to 2000 μg/L was observed for all the compounds (R² >0.998) and the limits of quantification for the 15 N-nitrosamines were 0.625-12.50 μg/kg (S/N=10), which were lower than the limits required by the EU 2009/48/EC Directive. The average recoveries of the target analytes at low, medium, and high spiked levels were in the ranges of 53.8%-116.2%, 52.7%-105.1% and 49.5%-102.9%, respectively. The average within-day and between-day RSDs were from 1.3% to 14.0% (n=6) and from 1.6% to 7.6% (n=4), respectively. The proposed method was used to monitor N-nitrosamines in baby nipples and balloons, and N-nitrosamines were found in some samples. The total contents of the 15 N-nitrosamines in the analyzed nipples and balloons samples ranged from 0.0499 mg/kg to 41.2 mg/kg. And the total contents of the N-nitrosatable substances in the analyzed samples ranged from 0.0264 mg/kg to 12.5 mg/kg.
- solid phase extraction (SPE),
- gas chromatography-tandem mass spectrometry (GC-MS/MS),
- N-nitrosamines,
- children’s latex articles
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