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Citation: WANG Hongrui, XIE Yuanyuan, LIANG Qionglin, WANG Yiming, HU Ping, LUO Guoan. Simultaneous determination of five Amadori compounds in tobacco by high performance liquid chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, ;2013, 31(12): 1189-1193. doi: 10.3724/SP.J.1123.2013.06029 shu

Simultaneous determination of five Amadori compounds in tobacco by high performance liquid chromatography-mass spectrometry

WANG Hongrui ^1,2 ,
XIE Yuanyuan ^2,, ,
LIANG Qionglin ² ,
WANG Yiming ² ,
HU Ping ¹ ,
LUO Guoan ^1,2,,

1.
1. School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;

Corresponding author: XIE Yuanyuan, LUO Guoan,
Received Date: 14 June 2013
Available Online: 8 September 2013
Fund Project:

A method of high performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-QqQ MS) in multiple reaction monitoring (MRM) mode for simultaneous determination of five Amadori compounds in tobacco has been developed. The separation was performed on an XBridge^TM Amide column (250 mm×4.6 mm, 3.5 μm) by gradient elution using methanol and water as mobile phases. The linearity of this method was good with the correlation coefficients (r) of 0.9895-0.9989. The limits of detection (S/N=3) were from 3.51 μg/L to 14.86 μg/L, and the limits of quantitation (S/N=10) were from 10.18 μg/L to 44.58 μg/L. The recoveries varied from 92.6% to 123.6% with the relative standard deviations (RSDs) less than 9.4%. The established method is rapid, accurate, robust and convenient, and it could be applied to the measurement of the five Amadori compounds in tobacco and cigarettes.
- high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS),
- Maillard reaction,
- Amadori compounds,
- precursor aroma,
- tobacco
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