Citation: ZHANG Ying, YANG Pengyuan, LU Haojie. Recent progress in multi-stage mass spectrometry-based quantitative proteomics[J]. Chinese Journal of Chromatography, ;2013, 31(6): 503-509. doi: 10.3724/SP.J.1123.2013.03056 shu

Recent progress in multi-stage mass spectrometry-based quantitative proteomics

1.
Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China

Corresponding author: LU Haojie,
Received Date: 29 March 2013
Available Online: 16 April 2013
Fund Project: 国家重点基础研究发展计划(2012CB910602,2012AA020203) (2012CB910602,2012AA020203)国家自然科学基金项目(21025519,21005020,31070732) (21025519,21005020,31070732)上海市项目(11XD1400800,东方学者,B109). (11XD1400800,东方学者,B109)

With the development of proteome research, quantitative proteomics is becoming a very active area of proteomics research. The development of quantitative proteomics requires the advancement of a number of mass spectrometry (MS)-based quantitative techniques. According to the mass spectrometric stage at which the peptides are quantified, MS-based quantitative methods can be divided into two categories: MS¹-based quantitation and MSⁿ-based quantitation. In this review, the progress of MSⁿ-based quantitation approaches is summarized and the advantages and disadvantages are compared. The trend of MSⁿ-based quantitation is also prospected.
- proteomics,
- mass spectrometry (MS),
- quantitative,
- review
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沈阳化工大学材料科学与工程学院沈阳 110142