Citation: LI Jingrui, MA Qiang, LI Wentao, WANG Chao, BAI Hua, MA Huijuan, CAI Tianpei, JIAO Yang, ZHANG Xiaoli. Determination of dioxane residue in cosmetics by isotope dilution-headspace gas chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, ;2013, 31(5): 481-484. doi: 10.3724/SP.J.1123.2013.01012 shu

Determination of dioxane residue in cosmetics by isotope dilution-headspace gas chromatography-mass spectrometry

LI Jingrui ¹ ,
MA Qiang ^1,, ,
LI Wentao ¹ ,
WANG Chao ¹ ,
BAI Hua ¹ ,
MA Huijuan ¹ ,
CAI Tianpei ¹ ,
JIAO Yang ² ,
ZHANG Xiaoli ²

1.
1. Chinese Academy of Inspection and Quarantine, Beijing 100123, China;

Corresponding author: MA Qiang,
Received Date: 6 January 2013
Available Online: 25 January 2013
Fund Project: 质检公益性行业科研专项项目(2012104013-4,2012104013-9) (2012104013-4,2012104013-9)国家质检总局科技计划项目(2011IK196) (2011IK196)国家标准化管理委员会计划项目(20101084-T-607) (20101084-T-607)国家科技支撑计划项目(2013BAK04B03). (2013BAK04B03)

A comprehensive analytical method based on isotope dilution-headspace gas chromatography-mass spectrometry was developed for the determination of dioxane residue in the cosmetics. Cosmetic sample (2 g) was placed in a headspace vial. Then, 1 g sodium chloride, 1 mL d₈-dioxane solution (20 mg/L) and 9 mL water were added. The vial was sealed and heated at 70 ℃ for 40 min. The qualitative and quantitative analyses were carried out for the analyte in selected ion monitoring (SIM) mode after the chromatographic separation on an HP-5MS column (30 m×0.25 mm×0.25 μm). The limit of quantification (LOQ) for dioxane was 2.5 mg/kg. The mean recoveries were 90.5%-104.0% at the spiked levels of 2.5-50 mg/kg with the relative standard deviations in the range of 1.26%-3.98%. The method is accurate, simple, rapid, and applicable for the inspection of dioxane residue in cosmetics.
- isotope dilution,
- headspace gas chromatography-mass spectrometry (HS-GC-MS),
- dioxane,
- cosmetics
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