Citation: HU Qinghong, WANG Chaoran, LI Jing, WANG Yan, GU Xue, YAN Chao. Enrichment of cis-diols active components in traditional Chinese medicines by boronate affinity monolithic column[J]. Chinese Journal of Chromatography, ;2013, 31(7): 714-717. doi: 10.3724/SP.J.1123.2012.12040 shu

Enrichment of cis-diols active components in traditional Chinese medicines by boronate affinity monolithic column

HU Qinghong ¹ ,
WANG Chaoran ¹ ,
LI Jing ^1,2 ,
WANG Yan ¹ ,
GU Xue ¹ ,
YAN Chao ^1,,

1.
1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;

Corresponding author: YAN Chao,
Received Date: 25 December 2012

Fund Project: 国家自然科学基金项目(21175092,21105064) (21175092,21105064)国家重大科学仪器设备开发专项(2011YQ150072,2011YQ15007204,2011YQ15007207,2011YQ15007210) (2011YQ150072,2011YQ15007204,2011YQ15007207,2011YQ15007210)上海市自然科学基金项目(12ZR1413600). (12ZR1413600)

A novel poly(4-vinylphenylboronic acid (VPBA)-co-pentaerythritol triacrylate (PETA)) monolithic column was prepared by thermal-initiated copolymerization of VPBA and PETA in a binary porogen system comprising diethylene glycol and ethylene glycol. The fabricated monolithic column demonstrated good boronate affinity property, which can specifically capture cis-diols containing compounds. We developed such a monolithic column and applied it to enrich active components in Herba Taraxaci and Euonymus acanthocarpus. The extracts of the two traditional Chinese medicines were separated and enriched on μ HPLC by the prepared monolith, and the fractions were collected and examined by HPLC. The results showed that the responses of the corresponding peaks were greatly improved, indicating that the poly(VPBA-co-PETA) monolithic column can be efficiently used to enrich active components in traditional Chinese medicines containing cis-diols group.
- boronate affinity,
- monolithic column,
- cis-diols compounds,
- active components,
- traditional Chinese medicine (TCM),
- enrichment
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