Citation: ZHENG Jun-Peng, ZHEN Ming-Ming, WANG Chun-Ru, SHU Chun-Ying. Recent Progress of Molecular Imaging Probes Based on Gadofullerenes[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(10): 1607-1615. doi: 10.3724/SP.J.1096.2012.20380 shu

Recent Progress of Molecular Imaging Probes Based on Gadofullerenes

1.
Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Corresponding author: SHU Chun-Ying,
Received Date: 11 April 2012
Available Online: 6 June 2012
Fund Project: 本文系国家自然科学基金(Nos.21121063, 51072200) (Nos.21121063, 51072200)NSAF联合基金(No.11076027)资助 (No.11076027)

Paramagnetic gadofullerenes and their derivatives exhibit much higher relaxivity than commercial Magnevist^TM (Gd-DTPA), therefore have become competitive candidates for magnetic (MR) imaging probes. More prominently, the stable fullerene cages are believed to hinder both chemical attack on the inner clusters and the escape of the toxic lanthanide ions, which should effectively suppress the toxicity of naked Gd³⁺ ions. Some functionalized gadofullerides also available for further conjugation to fabricate multifunctional probes. This review presents the latest finding of magnetic resonance imaging (MRI) probes based on various gadofullerenes, including Gd@C₆₀, Gd@C₈₂ and Gd₃N@C₈₀. The derivative strategy dependent relaxivity properties and biodistributions as well as their potential application as nanoplatform for multifunctional probe are reviewed and discussed.
- Molecular imaging,
- Endohedral metallofullerene,
- Magnetic resonance imaging,
- Review
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