Citation: HE Song-Jie, LI Ming-Yuan, JIN Jun, WANG Ying, HE Chang, BU Yun-Jie, TIAN Yang. Determination of New Halogenated Flame Retardants in Human Serum by Gel Permeation Chromatography-Gas Chromatography-Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(10): 1519-1523. doi: 10.3724/SP.J.1096.2012.20364 shu

Determination of New Halogenated Flame Retardants in Human Serum by Gel Permeation Chromatography-Gas Chromatography-Mass Spectrometry

1.
College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China

Corresponding author: JIN Jun,
Received Date: 6 April 2012
Available Online: 3 June 2012
Fund Project: 本文受到教育部新世纪优秀人才支持计划(No.NCET-10-0106 ) (No.NCET-10-0106 ) 中央民族大学985工程(No.MUC985-9) (No.MUC985-9)中央高校基本科研业务费专项资金中央民族大学自主科研计划项目(No.0910KYQN50)支持 (No.0910KYQN50)

A gel permeation chromatography-gas chromatography-negative chemical ionization-mass spectrometry method (GPC-GC-NCI-MS) was developed for the determination of 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and Dechlorane plus (DP) in human serum sample. The serum samples were spiked with ¹³C₁₂BB-153 and ¹³C₁₀syn-DP as surrogate internal standard before extracting, and the serum lipid was extracted and mostly removed by gel permeation chromatography. Samples were further cleaned up with a silica/sulfuric acid column. Identification and quantification of BB-153, BTBPE, syn-DP and anti-DP were performed by Gas chromatography-Negative chemical ionization-Mass spectrometry. The monitored ions were as follows: m/z 627.5 and 629.5 for BB-153; m/z 79 and 81 for BTBPE; m/z 652 and 654 for DP. The recoveries of ¹³C₁₂BB-153 and ¹³C₁₀syn-DP in serum samples were 91.5%±8.9% and 92.3%±8.1%, respectively. The limits of detection were from 0.6 to 1.2 ng/g lipid. BB-153 and BTBPE were not detected in all serum samples, and the concentrations of syn-DP and anti-DP were 0.7-9.2 ng/g lipid and 0.6-2.0 ng/g lipid, respectively.
1. [1]
  1 ZHANG Ying, WU Jiang-Ping, YU Le-Huan, HE Ming-Jing, LUO Xiao-Jun, MAI Bi-Xian. Environ. Chem., 2011, 30(1): 34-43
2. [2]
  张荧, 吴江平, 余乐洹, 何明靖, 罗孝俊, 麦碧娴. 环境化学, 2011, 30(1): 34-43
3. [3]
  2 Qiu X H, Zhu T, Hu J X. Chemosphere, 2010, 80(10): 1207-1212
4. [4]
  3 de Wit CA. Chemosphere, 2002, 46(5): 583-624
5. [5]
  4 Kohler M, Zennegg M, Bogdal C, Gerecke A C, Schmid P, Heeb N V, Sturm M, Vonmont H, Kohler H P, Giger W. Environ. Sci. Technol., 2008, 42(17): 6378-6384
6. [6]
  5 http://chm.pops.int/Programmes/NewPOPs/The9newPOPs/tabid/672/language/en-US/Default.aspx
7. [7]
  6 European Court of Justice. Cases C-14/06 and C-295/06, Judgement of the Court, 1 April 2008, Directive 2002/95/EC and Commission Decision 2005/717/EC;2008
8. [8]
  7 Hoh E, Zhu L Y, Hites R A. Environ. Sci. Technol., 2005, 39(8): 2472-2477
9. [9]
  8 Law K, Halldorson T, Danell R, Stern G, Gewurtz S, Alaee M, Marvin C, Whittle M, Tomy G. Environ. Toxicol. Chem., 2006, 25(8): 2177-2186
10. [10]
  9 Ren N, Sverko E, Li Y F, Zhang Z, Harner T, Wang D, Wan X, McCarry B E. Environ. Sci. Technol., 2008, 42(17): 6476-6480
11. [11]
  10 Hoh E, Zhu L, Hites R A. Environ. Sci. Technol., 2006, 40(4): 1184-1189
12. [12]
  11 de Wit C A, Herzke D, Vorkamp K.Sci. Total. Environ., 2010, 408(15): 2885-2918
13. [13]
  12 Xiao H, Hung H, Shen L, Wania F,Sverko E, Su Y S, Lei Y D, Reiner E, Kang S C, Barresi E, DeJong M. Proceedings of the BFR 2010 Conference, Kyoto, Japan, 7-9 April; 2010 www.bfr 2010.com/abstract-download/2010/90067.pdf
14. [14]
  13 Moller A, Xie Z Y, Cai M H, Sturm R, Ebinghaus R. Environ. Sci. Technol., 2012, 46(6): 3141-3148
15. [15]
  14 Hovander L, Athanasiadou M, Asplund L, Jensen S, Wehler E K. J. Anal. Toxicol., 2000, 24(8): 696-703
16. [16]
  15 REN Guo-Fa, LUO Xiang-Fan, MA Sheng-Tao, SUN Yan-Feng, YU Zhi-Qiang, SHENG Guo-Ying, FU Jia-Mo. Chinese J. Anal. Chem., 2011, 39(2): 235-238
17. [17]
  任国发, 罗湘凡, 马盛韬, 孙延枫, 于志强, 盛国英, 傅家谟. 分析化学, 2011, 39(2): 235-238
1. [1]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
2. [2]
  Yanhui Zhong , Ran Wang , Zian Lin . Analysis of Halogenated Quinone Compounds in Environmental Water by Dispersive Solid-Phase Extraction with Liquid Chromatography-Triple Quadrupole Mass Spectrometry. University Chemistry, 2024, 39(11): 296-303. doi: 10.12461/PKU.DXHX202402017
3. [3]
  Bairu Meng , Zongji Zhuo , Han Yu , Sining Tao , Zixuan Chen , Erik De Clercq , Christophe Pannecouque , Dongwei Kang , Peng Zhan , Xinyong Liu . Design, synthesis, and biological evaluation of benzo[4,5]thieno[2,3-d]pyrimidine derivatives as novel HIV-1 NNRTIs. Chinese Chemical Letters, 2024, 35(6): 108827-. doi: 10.1016/j.cclet.2023.108827
4. [4]
  Hui Li , Yanxing Qi , Jia Chen , Juanjuan Wang , Min Yang , Hongdeng Qiu . Synthesis of amine-pillar[5]arene porous adsorbent for adsorption of CO₂ and selectivity over N₂ and CH₄. Chinese Chemical Letters, 2024, 35(11): 109659-. doi: 10.1016/j.cclet.2024.109659
5. [5]
  Dong-Xue Jiao , Hui-Li Zhang , Chao He , Si-Yu Chen , Ke Wang , Xiao-Han Zhang , Li Wei , Qi Wei . Layered (C5H6ON)2[Sb2O(C2O4)3] with a large birefringence derived from the uniform arrangement of π-conjugated units. Chinese Journal of Structural Chemistry, 2024, 43(6): 100304-100304. doi: 10.1016/j.cjsc.2024.100304
6. [6]
  Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
7. [7]
  Peiyan Zhu , Yanyan Yang , Hui Li , Jinhua Wang , Shiqing Li . Rh(Ⅲ)‐Catalyzed sequential ring‐retentive/‐opening [4 + 2] annulations of 2H‐imidazoles towards full‐color emissive imidazo[5,1‐a]isoquinolinium salts and AIE‐active non‐symmetric 1,1′‐biisoquinolines. Chinese Chemical Letters, 2024, 35(10): 109533-. doi: 10.1016/j.cclet.2024.109533
8. [8]
  Shuangxi Li , Huijun Yu , Tianwei Lan , Liyi Shi , Danhong Cheng , Lupeng Han , Dengsong Zhang . NO_x reduction against alkali poisoning over Ce(SO₄)₂-V₂O₅/TiO₂ catalysts by constructing the Ce⁴⁺–SO₄²⁻ pair sites. Chinese Chemical Letters, 2024, 35(5): 108240-. doi: 10.1016/j.cclet.2023.108240
9. [9]
  Fan Wu , Wenchang Tian , Jin Liu , Qiuting Zhang , YanHui Zhong , Zian Lin . Core-Shell Structured Covalent Organic Framework-Coated Silica Microspheres as Mixed-Mode Stationary Phase for High Performance Liquid Chromatography. University Chemistry, 2024, 39(11): 319-326. doi: 10.12461/PKU.DXHX202403031
10. [10]
  Xuanzhu Huo , Yixi Liu , Qiyu Wu , Zhiqiang Dong , Chanzi Ruan , Yanping Ren . Integrated Experiment of “Electrolytic Preparation of Cu₂O and Gasometric Determination of Avogadro’s Constant: Implementation, Results, and Discussion: A Micro-Experiment Recommended for Freshmen in Higher Education at Various Levels Across the Nation. University Chemistry, 2024, 39(3): 302-307. doi: 10.3866/PKU.DXHX202308095
11. [11]
  Jiao Chen , Zihan Zhang , Guojin Sun , Yudi Cheng , Aihua Wu , Zefan Wang , Wenwen Jiang , Fulin Chen , Xiuying Xie , Jianli Li . Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders. Chinese Chemical Letters, 2024, 35(11): 110050-. doi: 10.1016/j.cclet.2024.110050
12. [12]
  Liyang ZHANG , Dongdong YANG , Ning LI , Yuanyu YANG , Qi MA . Crystal structures, luminescent properties and Hirshfeld surface analyses of three cadmium(Ⅱ) complexes based on 2-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)benzoate. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1943-1952. doi: 10.11862/CJIC.20240079
13. [13]
  Zhaoyang WANG , Chun YANG , Yaoyao Song , Na HAN , Xiaomeng LIU , Qinglun WANG . Lanthanide(Ⅲ) complexes derived from 4′-(2-pyridyl)-2, 2′∶6′, 2″-terpyridine: Crystal structures, fluorescent and magnetic properties. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1442-1451. doi: 10.11862/CJIC.20240114
14. [14]
  Xinlong WANG , Zhenguo CHENG , Guo WANG , Xiaokuen ZHANG , Yong XIANG , Xinquan WANG . Enhancement of the fragile interface of high voltage LiCoO₂ by surface gradient permeation of trace amounts of Mg/F. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 571-580. doi: 10.11862/CJIC.20230259
15. [15]
  Fan JIA , Wenbao XU , Fangbin LIU , Haihua ZHANG , Hongbing FU . Synthesis and electroluminescence properties of Mn²⁺ doped quasi-two-dimensional perovskites (PEA)₂Pb_yMn_1-yBr₄. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1114-1122. doi: 10.11862/CJIC.20230473
16. [16]
  Qingtang ZHANG , Xiaoyu WU , Zheng WANG , Xiaomei WANG . Performance of nano Li₂FeSiO₄/C cathode material co-doped by potassium and chlorine ions. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1689-1696. doi: 10.11862/CJIC.20240115
17. [17]
  Jiahong ZHENG , Jingyun YANG . Preparation and electrochemical properties of hollow dodecahedral CoNi₂S₄ supported by MnO₂ nanowires. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1881-1891. doi: 10.11862/CJIC.20240170
18. [18]
  Jingyu Cai , Xiaoyu Miao , Yulai Zhao , Longqiang Xiao . Exploratory Teaching Experiment Design of FeOOH-RGO Aerogel for Photocatalytic Benzene to Phenol. University Chemistry, 2024, 39(4): 169-177. doi: 10.3866/PKU.DXHX202311028
19. [19]
  Zhen Shi , Wei Jin , Yuhang Sun , Xu Li , Liang Mao , Xiaoyan Cai , Zaizhu Lou . Interface charge separation in Cu2CoSnS4/ZnIn2S4 heterojunction for boosting photocatalytic hydrogen production. Chinese Journal of Structural Chemistry, 2023, 42(12): 100201-100201. doi: 10.1016/j.cjsc.2023.100201
20. [20]
  Weizhong LING , Xiangyun CHEN , Wenjing LIU , Yingkai HUANG , Yu LI . Syntheses, crystal structures, and catalytic properties of three zinc(Ⅱ), cobalt(Ⅱ) and nickel(Ⅱ) coordination polymers constructed from 5-(4-carboxyphenoxy)nicotinic acid. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1803-1810. doi: 10.11862/CJIC.20240068

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(345)
HTML views(5)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142