Citation: DU Bi-Bai, XU Yang, Huang Yun-Hong, Kang Min. Determination of Sulfonamides in Feeds by High Performance Liquid Chromatography with Molecularly Imprinted Solid Phase Extraction[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(12): 1871-1876. doi: 10.3724/SP.J.1096.2012.20161 shu

Determination of Sulfonamides in Feeds by High Performance Liquid Chromatography with Molecularly Imprinted Solid Phase Extraction

DU Bi-Bai ¹ ,
XU Yang ^, ,
Huang Yun-Hong ^1,2 ,
Kang Min ¹

1.
¹ State Key Laboratory of Food Science and Technology, Sino-Germany Joint Research Institute, Nanchang University, Nanchang 330047, China;

Corresponding author: XU Yang,
Received Date: 22 February 2012
Available Online: 9 July 2012
Fund Project: 本文系食品科学与技术国家重点实验室自由探索课题(No.SKLF-TS-200815)资助 (No.SKLF-TS-200815)

A method was developed for monitoring five sulfonamides (SAs) in feeds by using molecularly imprinted polymers (MIPs) as selective solid-phase extraction sorbents coupled with high performance liquid chromatography. The MIPs were firstly synthesized by ultraviolet initiated using sulfadiazine as template. Then, the molecularly printed solid phase extraction (MISPE) column was prepared, and the MIPs were used as adsorbent. Meanwhile, the procedures of loading, washing and eluting conditions were optimized. Under the optimum conditions, the detection limit range of five SAs was 0.14-0.23 mg/kg and the quantification limit range was 0.38-0.47 mg/kg. The average recoveries were in the range of 72.1%-89.3% with a batch and batch sampling relative standard deviations less than 7.9% and 9.2%, respectively. It showed that the MISPE column decreased the matrix effect and had a better selectivity and a lower limit of quantification than Alumina B column.
- Molecularly imprinted polymer,
- Solid-phase extraction,
- Sulfonamides,
- Feed,
- High performance liquid chromatography
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