Citation: GAN Jing-Ni, CAI Zhuo, HE Xiao-Liang, QIU Xia-Lin, YUE Wei-Chao. Determination of Isoprenaline Hydrochloride Using Graphene-L-Cystine Composite Film Modified Glassy Carbon Electrode[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(12): 1877-1882. doi: 10.3724/SP.J.1096.2012.11429 shu

Determination of Isoprenaline Hydrochloride Using Graphene-L-Cystine Composite Film Modified Glassy Carbon Electrode

1.
College of Chemistry and Chemical Engineering, University of Guangxi, Nanning 530004, China

Corresponding author: CAI Zhuo,
Received Date: 11 April 2012
Available Online: 11 September 2012
Fund Project: 本文系广西自然科学基金(No.2010GXNSFA013001)资助项目 (No.2010GXNSFA013001)

A graphene-L-cystine modified glassy carbon electrode (GR-L-CysS/GCE) has been prepared. The electrochemical behavior of isoprenaline hydrochloride at the modified electrode has been studied. In 0.2 mol/L Na₂HPO₄-citric acid (pH 7.4) buffer, GR-L-CysS/GCE exhibited excellent catalytic and enhancement effect on the electrochemical oxidation of isoprenaline hydrochloride, and the oxidation peak current increased ca.13 times compared with that at bare GCE. The measurement parameters were optimized. Under the optimal conditions, isoprenaline hydrochloride concentration was linear with peak current in the range of 4.0×10^-6-1.6×10^-4 mol/L (R=0.9977), and the detection limit was 8.4×10^-7 mol/L(S/N=3). The mechanism investigation showed that the reaction of isoprenaline hydrochloride at the modified electrode was a process with one-proton and one-electron transfer, and the coefficient of electron transfer α is 0.4635. This method was successfully used in the determination of isoprenaline hydrochloride in injection with the recovery between 94.9%-102.9%.
- Graphene,
- L-Cystine,
- Chemically modified electrode,
- Isoprenaline hydrochloride,
- Electrochemical behavior
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