Citation: GU Hai-Wei, QI Yun-Peng, XU Ning, DING Jian-Hua, AN Yan-Bo, CHEN Huan-Wen. Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry-based Metabolomics for Cancer Diagnosis[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(12): 1933-1937. doi: 10.3724/SP.J.1096.2012.10542 shu

Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry-based Metabolomics for Cancer Diagnosis

1.
¹ Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang 330013, China;

Corresponding author: CHEN Huan-Wen,
Received Date: 28 May 2012
Available Online: 26 September 2012
Fund Project: 本文系国家自然科学基金(Nos.21005015,30901981) (Nos.21005015,30901981)国家重大仪器专项(No.2011YQ170067) (No.2011YQ170067)普度大学研究基金(美国)项目资助 (美国)

In this review, we aim to introduce a relatively new approach, metabolomics, and explore its potential for cancer diagnosis. We will briefly introduce the concept of metabolomics and its relationship with other omics studies in systems biology for cancer detection. The field of metabolomics focuses on the parallel measurement of hundreds of small molecule metabolites in biological samples such as blood, urine, and biopsied tissue. Since metabolite levels are sensitive to subtle changes in the pathological status, metabolomics promises novel avenues for early cancer detection and a better understanding of cancer processes. In fact, many previous metabolomics studies have clearly demons-trated the promises of metabolomics not only for the diagnosis of various kinds of cancer, but also for therapeutic monitoring as well as for drug development. In addition, in this review we will discuss the challenges and future directions for developing metabolomics methods towards clinical applications for cancer diagnosis.
- Nuclear magnetic resonance spectroscopy,
- Mass spectrometry,
- Metabolic profiling,
- Metabolomics,
- Cancer diagnosis,
- Oncology,
- Review
1. [1]
  1 Siegel R, Naishadham D, Jemal A. CA. Cancer J. Clin., 2012, 62(1): 10-29
2. [2]
  2 Ministry of Health, the People's Republic of China. Report on the Third National Sampling Survey of Causes of Death. Beijing: The People's Health Press, 2008
3. [3]
  3 Belkowski S M, Polkovitch D, D'Andrea M R. Curr. Top. Med. Chem., 2005, 5(11): 1047-1051
4. [4]
  4 Lu W L, Jansen L, Post W J, Bonnema J, Velde J C V d, Bock G H D. Breast Cancer Res. Treat., 2009, 114(3): 403-412
5. [5]
  5 Nicholson J K, Lindon J C, Holmes E. Xenobiotica, 1999, 29(11): 1181-1189
6. [6]
  6 Gowda G A N, Zhang S C, Gu H W, Asiago V, Shanaiah N, Raftery D. Expert Rev. Mol. Diagn., 2008, 8(5): 617-633
7. [7]
  7 Fiehn O. Plant Mol. Biol., 2002, 48(1-2): 155-171
8. [8]
  8 Wu Z M, Huang Z Q, Lehmann R, Zhao C X, Xu G W. Chromatographia, 2009, 69: S23-S32
9. [9]
  9 Tang H R, Wang Y L. Prog. Biochem. Biophys., 2006, 33(5): 401-417
10. [10]
  10 Heiden M G V, Cantley L C, Thompson C B. Science, 2009, 324(5930): 1029-1033
11. [11]
  11 Samudio I, Fiegl M, Andreeff M. Cancer Res., 2009, 69(6): 2163-2166
12. [12]
  12 Warburg O. Science, 1956, 123(3191): 309-314
13. [13]
  13 Takats Z, Wiseman J M, Gologan B, Cooks R G. Science, 2004, 306(5695): 471-473
14. [14]
  14 Cooks R G, Ouyang Z, Takats Z, Wiseman J M. Science, 2006, 311(5767): 1566-1570
15. [15]
  15 Cody R B, Laramee J A, Durst H D. Anal. Chem., 2005, 77(8): 2297-2302
16. [16]
  16 Chen H W, Venter A, Cooks R G. Chem. Commun., 2006, (19): 2042-2044
17. [17]
  17 Gu H W, Xu N, Chen H W. Anal. Bioanal. Chem., 2012, 403(8): 2145-2153
18. [18]
  18 Broadhurst D I, Kell D B. Metabolomics, 2006, 2(4): 171-196
19. [19]
  19 Raftery D, Gowda G A N. J. Urol., 2008, 179(6): 2089-2090
20. [20]
  20 Bathe O F, Shaykhutdinov R, Kopciuk K, Weljie A M, Mckay A, Sutherland F R, Dixon E, Dunse N, Sotiropoulos D, Vogel H J. Cancer Epidem. Biomar., 2011, 20(1): 140-147
21. [21]
  21 Odunsi K, Wollman R M, Ambrosone C B, Hutson A, McCann S E, Tammela J, Geisler J P, Miller G, Sellers T, Cliby W, Qian F, Keitz B, Intengan M, Lele S, Alderfer J L. Int. J. Cancer, 2005, 113(5): 782-788
22. [22]
  22 Rantalainen M, Cloarec O, Beckonert O, Wilson I D, Jackson D, Tonge R, Rowlinson R, Rayner S, Nickson J, Wilkinson R W, Mills J D, Trygg J, Nicholson J K, Holmes E. J. Proteome Res., 2006, 5(10): 2642-2655
23. [23]
  23 Chen H W, Pan Z Z, Talaty N, Raftery D, Cooks R G. Rapid Commun. Mass Spectrom., 2006, 20(10): 1577-1584
24. [24]
  24 Fan T W, Lane A N, Higashi R M, Farag M A, Gao H, Bousamra M, Miller D M. Mol. Cancer, 2009, 8: 41
25. [25]
  25 Chen J, Wang W Z, Lv S, Yin P Y, Zhao X J, Lu X, Zhang F X, Xu G W. Anal. Chim. Acta, 2009, 650(1): 3-9
26. [26]
  26 Sitter B, Lundgren S, Bathen T F, Halgunset J, Fjosne H E, Gribbestad I S. NMR Biomed., 2006, 19(1): 30-4027 Asiago V M, Alvarado L Z, Shanaiah N, Gowda G A N, Owusu-Sarfo K, Ballas R A, Raftery D. Cancer Res., 2010, 70(21): 8309-8318
27. [27]
  28 Pan Z Z, Raftery D. Anal. Bioanal.Chem., 2007, 387(2): 525-527
28. [28]
  29 Gu H W, Pan Z Z, Xi B W, Asiago V, Musselman B, Raftery D. Anal. Chim. Acta, 2011, 686(1-2): 57-63
29. [29]
  30 Wang D J, Bodovitz S. Trends Biotechnol., 2010, 28(6): 281-290
30. [30]
  31 D'Alessandro A, Zolla L. Drug Discov. Today, 2012, 17(1-2): 3-9
31. [31]
  32 Wishart D S, Tzur D, Knox C, Eisner R, Guo A C, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly M A, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau D D, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan G E, MacInnis G D, Weljie A M, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes B D, Vogel H J, Querengesser L. Nucleic Acids Res., 2007, 35: D521-D526
32. [32]
  33 Kanehisa M. In Silico Simulation of Biological Processes, 2002, 247: 91-103
33. [33]
  34 http://webbook.nist.gov/chemistry/
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