Citation: GU Hai-Wei, QI Yun-Peng, XU Ning, DING Jian-Hua, AN Yan-Bo, CHEN Huan-Wen. Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry-based Metabolomics for Cancer Diagnosis[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(12): 1933-1937. doi: 10.3724/SP.J.1096.2012.10542 shu

Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry-based Metabolomics for Cancer Diagnosis

1.
¹ Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang 330013, China;

Corresponding author: CHEN Huan-Wen,
Received Date: 28 May 2012
Available Online: 26 September 2012
Fund Project: 本文系国家自然科学基金(Nos.21005015,30901981) (Nos.21005015,30901981)国家重大仪器专项(No.2011YQ170067) (No.2011YQ170067)普度大学研究基金(美国)项目资助 (美国)

In this review, we aim to introduce a relatively new approach, metabolomics, and explore its potential for cancer diagnosis. We will briefly introduce the concept of metabolomics and its relationship with other omics studies in systems biology for cancer detection. The field of metabolomics focuses on the parallel measurement of hundreds of small molecule metabolites in biological samples such as blood, urine, and biopsied tissue. Since metabolite levels are sensitive to subtle changes in the pathological status, metabolomics promises novel avenues for early cancer detection and a better understanding of cancer processes. In fact, many previous metabolomics studies have clearly demons-trated the promises of metabolomics not only for the diagnosis of various kinds of cancer, but also for therapeutic monitoring as well as for drug development. In addition, in this review we will discuss the challenges and future directions for developing metabolomics methods towards clinical applications for cancer diagnosis.
- Nuclear magnetic resonance spectroscopy,
- Mass spectrometry,
- Metabolic profiling,
- Metabolomics,
- Cancer diagnosis,
- Oncology,
- Review
1. [1]
  1 Siegel R, Naishadham D, Jemal A. CA. Cancer J. Clin., 2012, 62(1): 10-29
2. [2]
  2 Ministry of Health, the People's Republic of China. Report on the Third National Sampling Survey of Causes of Death. Beijing: The People's Health Press, 2008
3. [3]
  3 Belkowski S M, Polkovitch D, D'Andrea M R. Curr. Top. Med. Chem., 2005, 5(11): 1047-1051
4. [4]
  4 Lu W L, Jansen L, Post W J, Bonnema J, Velde J C V d, Bock G H D. Breast Cancer Res. Treat., 2009, 114(3): 403-412
5. [5]
  5 Nicholson J K, Lindon J C, Holmes E. Xenobiotica, 1999, 29(11): 1181-1189
6. [6]
  6 Gowda G A N, Zhang S C, Gu H W, Asiago V, Shanaiah N, Raftery D. Expert Rev. Mol. Diagn., 2008, 8(5): 617-633
7. [7]
  7 Fiehn O. Plant Mol. Biol., 2002, 48(1-2): 155-171
8. [8]
  8 Wu Z M, Huang Z Q, Lehmann R, Zhao C X, Xu G W. Chromatographia, 2009, 69: S23-S32
9. [9]
  9 Tang H R, Wang Y L. Prog. Biochem. Biophys., 2006, 33(5): 401-417
10. [10]
  10 Heiden M G V, Cantley L C, Thompson C B. Science, 2009, 324(5930): 1029-1033
11. [11]
  11 Samudio I, Fiegl M, Andreeff M. Cancer Res., 2009, 69(6): 2163-2166
12. [12]
  12 Warburg O. Science, 1956, 123(3191): 309-314
13. [13]
  13 Takats Z, Wiseman J M, Gologan B, Cooks R G. Science, 2004, 306(5695): 471-473
14. [14]
  14 Cooks R G, Ouyang Z, Takats Z, Wiseman J M. Science, 2006, 311(5767): 1566-1570
15. [15]
  15 Cody R B, Laramee J A, Durst H D. Anal. Chem., 2005, 77(8): 2297-2302
16. [16]
  16 Chen H W, Venter A, Cooks R G. Chem. Commun., 2006, (19): 2042-2044
17. [17]
  17 Gu H W, Xu N, Chen H W. Anal. Bioanal. Chem., 2012, 403(8): 2145-2153
18. [18]
  18 Broadhurst D I, Kell D B. Metabolomics, 2006, 2(4): 171-196
19. [19]
  19 Raftery D, Gowda G A N. J. Urol., 2008, 179(6): 2089-2090
20. [20]
  20 Bathe O F, Shaykhutdinov R, Kopciuk K, Weljie A M, Mckay A, Sutherland F R, Dixon E, Dunse N, Sotiropoulos D, Vogel H J. Cancer Epidem. Biomar., 2011, 20(1): 140-147
21. [21]
  21 Odunsi K, Wollman R M, Ambrosone C B, Hutson A, McCann S E, Tammela J, Geisler J P, Miller G, Sellers T, Cliby W, Qian F, Keitz B, Intengan M, Lele S, Alderfer J L. Int. J. Cancer, 2005, 113(5): 782-788
22. [22]
  22 Rantalainen M, Cloarec O, Beckonert O, Wilson I D, Jackson D, Tonge R, Rowlinson R, Rayner S, Nickson J, Wilkinson R W, Mills J D, Trygg J, Nicholson J K, Holmes E. J. Proteome Res., 2006, 5(10): 2642-2655
23. [23]
  23 Chen H W, Pan Z Z, Talaty N, Raftery D, Cooks R G. Rapid Commun. Mass Spectrom., 2006, 20(10): 1577-1584
24. [24]
  24 Fan T W, Lane A N, Higashi R M, Farag M A, Gao H, Bousamra M, Miller D M. Mol. Cancer, 2009, 8: 41
25. [25]
  25 Chen J, Wang W Z, Lv S, Yin P Y, Zhao X J, Lu X, Zhang F X, Xu G W. Anal. Chim. Acta, 2009, 650(1): 3-9
26. [26]
  26 Sitter B, Lundgren S, Bathen T F, Halgunset J, Fjosne H E, Gribbestad I S. NMR Biomed., 2006, 19(1): 30-4027 Asiago V M, Alvarado L Z, Shanaiah N, Gowda G A N, Owusu-Sarfo K, Ballas R A, Raftery D. Cancer Res., 2010, 70(21): 8309-8318
27. [27]
  28 Pan Z Z, Raftery D. Anal. Bioanal.Chem., 2007, 387(2): 525-527
28. [28]
  29 Gu H W, Pan Z Z, Xi B W, Asiago V, Musselman B, Raftery D. Anal. Chim. Acta, 2011, 686(1-2): 57-63
29. [29]
  30 Wang D J, Bodovitz S. Trends Biotechnol., 2010, 28(6): 281-290
30. [30]
  31 D'Alessandro A, Zolla L. Drug Discov. Today, 2012, 17(1-2): 3-9
31. [31]
  32 Wishart D S, Tzur D, Knox C, Eisner R, Guo A C, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly M A, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau D D, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan G E, MacInnis G D, Weljie A M, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes B D, Vogel H J, Querengesser L. Nucleic Acids Res., 2007, 35: D521-D526
32. [32]
  33 Kanehisa M. In Silico Simulation of Biological Processes, 2002, 247: 91-103
33. [33]
  34 http://webbook.nist.gov/chemistry/
1. [1]
  Wei Shao , Wanqun Zhang , Pingping Zhu , Wanqun Hu , Qiang Zhou , Weiwei Li , Kaiping Yang , Xisheng Wang . Design and Practice of Ideological and Political Cases in the Course of Instrument Analysis Experiment: Taking the GC-MS Experiment as an Example. University Chemistry, 2024, 39(2): 147-154. doi: 10.3866/PKU.DXHX202309048
2. [2]
  Haolin Zhan , Qiyuan Fang , Jiawei Liu , Xiaoqi Shi , Xinyu Chen , Yuqing Huang , Zhong Chen . Noise Reduction of Nuclear Magnetic Resonance Spectroscopy Using Lightweight Deep Neural Network. Acta Physico-Chimica Sinica, 2025, 41(2): 2310045-0. doi: 10.3866/PKU.WHXB202310045
3. [3]
  Qian Wu , Yuanxia Lv , Zixuan Guo , Zhihao Zhao , Zhimin Zhang , Hongmei Lu . A Case Study and Practice of Research-Oriented Comprehensive Instrumental Analysis Laboratory Courses. University Chemistry, 2025, 40(10): 194-202. doi: 10.12461/PKU.DXHX202411063
4. [4]
  Hao Wu , Zhen Liu , Dachang Bai . ¹H NMR Spectrum of Amide Compounds. University Chemistry, 2024, 39(3): 231-238. doi: 10.3866/PKU.DXHX202309020
5. [5]
  Zhuoming Liang , Ming Chen , Zhiwen Zheng , Kai Chen . Multidimensional Studies on Ketone-Enol Tautomerism of 1,3-Diketones By ¹H NMR. University Chemistry, 2024, 39(7): 361-367. doi: 10.3866/PKU.DXHX202311029
6. [6]
  Jinkang Jin , Yidian Sheng , Ping Lu , Zhan Lu . Introducing a Website for Learning Nuclear Magnetic Resonance (NMR) Spectrum Analysis. University Chemistry, 2024, 39(11): 388-396. doi: 10.12461/PKU.DXHX202403054
7. [7]
  Haiyang Jin , Yonghai Hui , Yongfei Zhang , Lijun Gao , Yun Wang . Application and Exploration of Nuclear Magnetic Resonance Spectrometer in Undergraduate Basic Laboratory Teaching. University Chemistry, 2025, 40(3): 245-250. doi: 10.12461/PKU.DXHX202406022
8. [8]
  Yue-Zhou Zhu , Kun Wang , Shi-Sheng Zheng , Hong-Jia Wang , Jin-Chao Dong , Jian-Feng Li . Application and Development of Electrochemical Spectroscopy Methods. Acta Physico-Chimica Sinica, 2024, 40(3): 2304040-0. doi: 10.3866/PKU.WHXB202304040
9. [9]
  Zian Lin , Yingxue Jin . Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Disease Marker Screening and Identification: A Comprehensive Experiment Teaching Reform in Instrumental Analysis. University Chemistry, 2024, 39(11): 327-334. doi: 10.12461/PKU.DXHX202403066
10. [10]
  Linghua Chen . 基于双联动“三学”模式的食品专业分析化学教学改革. University Chemistry, 2025, 40(8): 78-91. doi: 10.12461/PKU.DXHX202409095
11. [11]
  Yan Su , Xiuyun Wang , Huimin Guo , Yanjuan Zhang , Xinwen Zhang , Yunting Shang , Wenfeng Jiang . To Cultivate Scientific Literacy by Learning, Thinking, Practicing and Understanding, To Utilize the “Smart Eye” Expertise by Integrating of Knowledge and Action: Ideological and Political Construction of Analytical Chemistry Experiment Course. University Chemistry, 2024, 39(2): 196-202. doi: 10.3866/PKU.DXHX202308003
12. [12]
  Weiwei Zhang , Yongxin Ren , Hong Zhang , Ke Lu . Current Situation and Quality Improvement Measures of Undergraduate Education in Modern Analytical Testing Technology under the “Learning, Teaching, and Practicing” Trinity Concept. University Chemistry, 2025, 40(10): 78-85. doi: 10.12461/PKU.DXHX202412006
13. [13]
  Jin Tong , Shuyan Yu . Crystal Engineering for Supramolecular Chirality. University Chemistry, 2024, 39(3): 86-93. doi: 10.3866/PKU.DXHX202308113
14. [14]
  Xianfei Chen , Wentao Zhang , Haiying Du . Experimental Design of Computational Materials Science Based on Scientific Research Cases. University Chemistry, 2025, 40(3): 52-61. doi: 10.3866/PKU.DXHX202403112
15. [15]
  Mi Wen , Baoshuo Jia , Yongqi Chai , Tong Wang , Jianbo Liu , Hailong Wu . Improvement of Fluorescence Quantitative Analysis Experiment: Simultaneous Determination of Rhodamine 6G and Rhodamine 123 in Food Using Chemometrics-Assisted Three-Dimensional Fluorescence Method. University Chemistry, 2025, 40(4): 390-398. doi: 10.12461/PKU.DXHX202405147
16. [16]
  Hongwei Ma , Fang Zhang , Hui Ai , Niu Zhang , Shaochun Peng , Hui Li . Integrated Crystallographic Teaching with X-ray,TEM and STM. University Chemistry, 2024, 39(3): 5-17. doi: 10.3866/PKU.DXHX202308107
17. [17]
  Jiantao Zai , Hongjin Chen , Xiao Wei , Li Zhang , Li Ma , Xuefeng Qian . The Learning-Centered Problem-Oriented Experimental Teaching. University Chemistry, 2024, 39(4): 40-47. doi: 10.3866/PKU.DXHX202309023
18. [18]
  Yang Liu , Peng Chen , Lei Liu . Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook. University Chemistry, 2024, 39(10): 45-51. doi: 10.12461/PKU.DXHX202407085
19. [19]
  Weitai Wu , Laiying Zhang , Yuan Chun , Liang Qiao , Bin Ren . Course Design of Chemical Measurement Experiments in Chemistry “101 Plan”. University Chemistry, 2024, 39(10): 64-68. doi: 10.12461/PKU.DXHX202409031
20. [20]
  Tianyu Feng , Guifang Jia , Peng Zou , Jun Huang , Zhanxia Lü , Zhen Gao , Chu Wang . Construction of the Chemistry Biology Experiment Course in the Chemistry “101 Program”. University Chemistry, 2024, 39(10): 69-77. doi: 10.12461/PKU.DXHX202409002

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(445)
HTML views(47)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142