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Citation: TAN Funeng, HE Yuanyuan, SUI Weiping. Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and(2-Hydroxy-3-butoxy) propyl Hydroxypropyl Chitosan[J]. Chinese Journal of Applied Chemistry, ;2014, 31(12): 1399-1404. doi: 10.3724/SP.J.1095.2014.40072 shu

Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and(2-Hydroxy-3-butoxy) propyl Hydroxypropyl Chitosan

1.
a Chemical and Engineering Institute, Wenshan University, Wenshan 663000, China;
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b Wenshan City Agricultural Enviroment Protection and Monitoring Station, Wenshan 663000, China;
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c College of Chemistry and Chemical Engineering, University of Ji'nan, Ji'nan 250022, China

Corresponding author: TAN Funeng,
Received Date: 11 March 2014
Available Online: 28 May 2014
Fund Project: 云南省科技厅应用基础研究计划青年项目(2012FD058) (2012FD058)

(2-Hydroxy-3-butoxy) propyl hydroxypropyl chitosan(2-H-3-B-P-HPCS) was synthesized to prepare 2-H-3-B-P-HPCS/polyethylene glycol(2-H-3-B-P-HPCS/PEG) interpenetrating polymer network(IPN) hydrogels.The factors that could influence swelling properties of 2-H-3-B-P-HPCS/PEG IPN hydrogels were studied,such as concentration of 2-H-3-B-P-HPCS,reaction temperature,amount of PEG and glutaral.The 2-H-3-B-P-HPCS/PEG IPN hydrogels were investigated by SEM and IR.Aciclovir as a model drug was used to study the release performance.The results show that 2-H-3-B-P-HPCS/PEG IPN hydrogels have good swelling property,pH sensibility and drug releasing ability and can be used for a new drug carrier.
- (hydroxy-butoxy) propyl-hydroxypropyl chitosan,
- polyethylene glycol,
- hydrogel,
- drug release
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